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Caspase-3 is one of the cystein proteases that play essential roles in programmed cell death. As such, brain development is profoundly affected by caspase-3-deficiency, resulting in hyperplasia and abnormal cell organization (Kuida et al., Nature 1996;384:368–372). In the present study, we used caspase-3 (−/−) mice to show that caspase-3 deficiency results in severe hearing loss, hyperplasia of supporting...