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IFNα/β, IL-12, and IL-15 regulate NK cell activation and expansion, but signals triggering resolution of the NK response upon induction of adaptive immunity remain to be defined. We now report that IL-21, a product of activated T cells, may serve this function. Mice lacking IL-21R (IL-21R -/- ) had normal NK cell development but no detectable responses to IL-21. IL-21 enhanced cytotoxic...