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Nous rapportons le cas d'un homme de 53 ans presentant un syndrome de Cushing du a une hyperplasie macronodulaire des surrenales (AIMAH des auteurs anglo-saxons). Sa cortisolemie etait elevee avec disparition du rythme circadien et absence de diminution malgre de fortes doses de dexamethasone. Son ACTH plasmatique etait indetectable et n'etait pas stimulable par la CRH (Corticotrophin-Releasing Hormone)...