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Exposure to cadmium (Cd) disrupts bone metabolism, causing osteoporosis. Impaired vitamin D metabolism was initially proposed as the underlying mechanism, yet recent studies argue for the direct effect of Cd on bone cells. This study aimed at characterizing 109 Cd uptake and cytotoxicity in MC3T3-E1 osteoblasts. Time-dependent accumulation of 109 Cd was observed with a 50% lethal concentration...