Search results for: James P. Hamilton

Items from 1 to 20 out of 46 results

article

Critical interactions between race and the highly granular area deprivation index in liver transplant evaluation

Alexandra T. Strauss, Eric Moughames, John W. Jackson, Daniel Malinsky, more

Clinical Transplantation > 37 > 5 > n/a - n/a

Neighborhood socioeconomic deprivation may have important implications on disparities in liver transplant (LT) evaluation. In this retrospective cohort study, we constructed a novel dataset by linking individual patient‐level data with the highly granular Area Deprivation Index (ADI), which is advantageous over other neighborhood measures due to: specificity of Census Block‐Group (versus Census Tract,...

article

Multicenter study of racial and ethnic inequities in liver transplantation evaluation: Understanding mechanisms and identifying solutions

Alexandra T. Strauss, Carolyn N. Sidoti, Tanjala S. Purnell, Hannah C. Sung, more

Liver Transplantation > 28 > 12 > 1841 - 1856

Racial and ethnic disparities persist in access to the liver transplantation (LT) waiting list; however, there is limited knowledge about underlying system‐level factors that may be responsible for these disparities. Given the complex nature of LT candidate evaluation, a human factors and systems engineering approach may provide insights. We recruited participants from the LT teams (coordinators,...

article

HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

Christine M. Durand, Sander Florman, Jennifer D. Motter, Diane Brown, more

American Journal of Transplantation > 22 > 3 > 853 - 864

Liver transplantation (LT) from donors‐with‐HIV to recipients‐with‐HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single‐case reports of HIV D+/R+ LT, each with limited follow‐up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors‐without‐HIV to recipients‐with‐HIV (HIV D−/R+) LT. We quantified patient survival, graft survival, rejection,...

article

Liver Transplantation in Short Telomere‐Mediated Hepatopulmonary Syndrome Following Bone Marrow Transplantation Using HCV Positive Allografts: A Case Series

Abdul M. Oseini, James P. Hamilton, Muhammad Baraa Hammami, Ahyoung Kim, more

Liver Transplantation > 27 > 12 > 1844 - 1848

article

Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade

Jaclyn LoPiccolo, Michael I. Brener, Kiyoko Oshima, Evan J. Lipson, more

Hepatology > 68 > 6 > 2431 - 2433

article

Mo1456 - Clinical Characteristic and Outcomes in Primary Sclerosing Cholangitis Following Liver Transplantation – A Single Center Experience

Tokunbo Ajayi, Behnam Saberi, Christopher Fain, Reezwana Chowdhury, more

Gastroenterology > 2018 > 154 > 6(S1) > S-1212

article

Sa1544 - Impact of Pre Versus Post Liver Transplant HCV Treatment with Direct-Acting Antivirals on Post Liver Transplant Survival

Alexandra T. Strauss, Sharon R. Weeks, Christine Durand, James P. Hamilton, more

Gastroenterology > 2018 > 154 > 6(S1) > S-1150-S-1151

article

Utilization of hepatitis C virus RNA–positive donor liver for transplant to hepatitis C virus RNA–negative recipient

Behnam Saberi, James P. Hamilton, Christine M. Durand, Zhiping Li, more

Liver Transplantation > 24 > 1 > 140 - 143

article

Patients Transplanted for Metabolic and Viral Causes of Cirrhosis Have Similar Outcomes After Five Years

Nikhilesh R. Mazumder, Behnam Saberi, James P. Hamilton, Andrew Cameron, more

Gastroenterology > 2017 > 152 > 5(S1) > S1135

article

Coronary Artery Calcium Score for Cardiac Risk Stratification: A Retrospective Analysis of Simultaneous Liver-Kidney, Living-Donor and Cadaveric Liver Transplant Recipients

Jessica Shay, Stuart Russell, Aliaksei Pustavoitau, Kawtar Al Khalloufi, more

Gastroenterology > 2017 > 152 > 5(S1) > S1127

article

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Yumin Oh, Ogyi Park, Magdalena Swierczewska, James P. Hamilton, more

Hepatology > 64 > 1 > 209 - 223

Liver fibrosis is a common outcome of chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. No US Food and Drug Administration–approved targeted antifibrotic therapy exists. Activated hepatic stellate cells (aHSCs) are the major cell types responsible for liver fibrosis; therefore, eradication of aHSCs, while preserving quiescent HSCs and other normal cells, is a logical...

article

Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B^−/− (Wilson disease) mice

James P. Hamilton, Lahari Koganti, Abigael Muchenditsi, Venkata S. Pendyala, more

Hepatology > 63 > 6 > 1828 - 1841

Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is based on copper chelation, which decreases the manifestations of liver disease, but often worsens neurological symptoms. We demonstrate that in Atp7b^−/− mice, an animal model of WD, liver function can be significantly improved...

article

Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model

Swathi Karthikeyan, James J. Potter, Jean-Francois Geschwind, Surojit Sur, more

Biochemical and Biophysical Research Communications > 2016 > 469 > 3 > 463-469

Liver fibrosis and cirrhosis result from uncontrolled secretion and accumulation of extracellular matrix (ECM) proteins by hepatic stellate cells (HSCs) that are activated by liver injury and inflammation. Despite the progress in understanding the biology liver fibrogenesis and the identification of potential targets for treating fibrosis, development of an effective therapy remains elusive. Since...

article

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Surbhi Jain, Lijia Xie, Batbold Boldbaatar, Selena Y. Lin, more

Hepatology Research > 45 > 11 > 1110 - 1123

AimAberrant methylation of the promoter, P2, and the first exon, E1, regions of the tumor suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC), albeit with poor specificity. This study analyzed the methylation profiles of P1, P2 and E1 regions of the gene to identify the region of which methylation most specifically corresponds to HCC and to evaluate the potential of this...

article

Su1014 The Association Between Pre-Orthotopic Liver Transplant Transthoracic Echocardiogram Findings and 6 Month Post-Transplant Outcomes: A Case-Control Analysis

Monica Konerman, Jennifer Price, Catherine Campbell, Swathi Eluri, more

Gastroenterology > 2015 > 148 > 4(S1) > S-1037-S-1038

article

Effects of vitamin D3 stimulation of thioredoxin‐interacting protein in hepatocellular carcinoma

James P. Hamilton, James J. Potter, Lahari Koganti, Stephen J. Meltzer, more

Hepatology Research > 44 > 13 > 1357 - 1366

AimThioredoxin‐interacting protein (TXNIP) promotes oxidative stress by inactivating thioredoxin (TXN). This protein is involved in diverse disease processes, including insulin resistance, atherosclerosis and carcinogenesis. The aim of the present study was to measure the expression and function of TXNIP in in vitro models of liver disease, as well as in primary human hepatocellular carcinoma (HCC)...

article

Sa1029 Clostridium difficile Infection Among Patients Who Have Undergone Orthotropic Liver Transplantation

Shashank Garg, Amy Wozniak, Shmuel Shoham, James P. Hamilton, more

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-942

article

Mo1278 The Effect of Pre-Operative Transarterial Chemoembolization Upon Risk of Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Shazia M. Siddique, David W. Victor, Mariana Lazo, James P. Hamilton

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-605-S-606

chapter

Nanomechanical characterization of graphene platelets in polypropylene-based graphene nanocomposites using atomic force microscopy

Jorge Camacho, Kjerstin Gronski, Robinson Flaig, Yan Wu, more

2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013) > 808 - 812

2013 IEEE 13th International Conference on Nanotechnology (IEEE-NANO)

Atomic force microscopy (AFM) operated in tapping mode was used to simultaneously obtain topographical, phase and loss tangent scans of polypropylene-graphene nanocomposite. This polymer nanocomposite was loaded with five percentage of graphene by weight. AFM force-distance curves were generated to further investigate the elasticity and adhesion of the polymer nanocomposite and to distinguish regions...

article

Elevated ALT and GGT predict all-cause mortality and hepatocellular carcinoma in Taiwanese male: a case-cohort study

Ruben Hernaez, Hsin-Chieh Yeh, Mariana Lazo, Hui-Ming Chung, more

Hepatology International > 2013 > 7 > 4 > 1040-1049

Purpose Evidence indicates a positive association between liver enzymes and the risk of death in Western countries; however, the evidence in Asian populations is scarce. We investigated the association between liver enzymes and total, cardiovascular (CVD), cancer and hepatocellular carcinoma (HCC) mortality in a cohort of Taiwanese male free of cancer at baseline. Methods From 1996 to 2003, 54,751...

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American Journal of Transplantation (1)
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INFONA - science communication portal

Search results for: James P. Hamilton

Critical interactions between race and the highly granular area deprivation index in liver transplant evaluation

Multicenter study of racial and ethnic inequities in liver transplantation evaluation: Understanding mechanisms and identifying solutions

HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

Liver Transplantation in Short Telomere‐Mediated Hepatopulmonary Syndrome Following Bone Marrow Transplantation Using HCV Positive Allografts: A Case Series

Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade

Mo1456 - Clinical Characteristic and Outcomes in Primary Sclerosing Cholangitis Following Liver Transplantation – A Single Center Experience

Sa1544 - Impact of Pre Versus Post Liver Transplant HCV Treatment with Direct-Acting Antivirals on Post Liver Transplant Survival

Utilization of hepatitis C virus RNA–positive donor liver for transplant to hepatitis C virus RNA–negative recipient

Patients Transplanted for Metabolic and Viral Causes of Cirrhosis Have Similar Outcomes After Five Years

Coronary Artery Calcium Score for Cardiac Risk Stratification: A Retrospective Analysis of Simultaneous Liver-Kidney, Living-Donor and Cadaveric Liver Transplant Recipients

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B^−/− (Wilson disease) mice

Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Su1014 The Association Between Pre-Orthotopic Liver Transplant Transthoracic Echocardiogram Findings and 6 Month Post-Transplant Outcomes: A Case-Control Analysis

Effects of vitamin D3 stimulation of thioredoxin‐interacting protein in hepatocellular carcinoma

Sa1029 Clostridium difficile Infection Among Patients Who Have Undergone Orthotropic Liver Transplantation

Mo1278 The Effect of Pre-Operative Transarterial Chemoembolization Upon Risk of Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Nanomechanical characterization of graphene platelets in polypropylene-based graphene nanocomposites using atomic force microscopy

Elevated ALT and GGT predict all-cause mortality and hepatocellular carcinoma in Taiwanese male: a case-cohort study

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