Search results for: Gunay Yetik Anacak

Items from 1 to 13 out of 13 results

article

Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum

Elif Alan, Gokay Albayrak, Gulnur Sevin, Gunay Yetik‐Anacak, more

Erectile dysfunction (ED) is the inability to achieve/maintain an erection. Because of the side effects, interactions, or ineffectiveness of currently used drugs, novel drug discovery studies are ongoing. The roots of Turkish endemic plants Prangos uechtritzii and Prangos heyniae are traditionally used as aphrodisiacs in Anatolia and contain coumarin‐like relaxant compounds. This study aims to reveal...

article

The role of resistin on metabolic syndrome‐induced erectile dysfunction and the possible therapeutic effect of Boldine

Erkan Kara, Erkan Kahraman, Ezgi Dayar, Gunay Yetik Anacak, more

Andrology > 8 > 6 > 1728 - 1735

Background Resistin is known as a potential mediator of obesity‐associated insulin resistance. The high resistin level disrupts nitric oxide (NO)‐mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti‐diabetic and protects endothelial functions. Objectives We aimed to investigate resistin expression in penile tissue in the presence of...

article

The anti-angiogenic potential of (±) gossypol in comparison to suramin

Gönül Ulus, A. Tansu Koparal, Kemal Baysal, Günay Yetik Anacak, more

Cytotechnology > 2018 > 70 > 6 > 1537-1550

Cotton, a staple fiber that grows around the seeds of the cotton plants (Gossypium), is produced throughout the world, and its by products, such as cotton fibers, cotton-seed oil, and cottonseed proteins, have a variety of applications. Cotton-seed contains gossypol, a natural phenol compound. (±)-Gossypol is a yellowish polyphenol that is derived from different parts of the cotton plant and contains...

article

The role of eNOS on the compensatory regulation of vascular tonus by H2S in mouse carotid arteries

Elif Ertuna, Annemarieke E. Loot, Ingrid Fleming, Gunay Yetik-Anacak

Nitric Oxide > 2017 > 69 > C > 45-50

The gasotransmitter nitric oxide (NO) has an important role in vascular function and a decrease in its bioavailability is accepted as a main pathological mechanism for cardiovascular diseases. However, other gasotransmitters such as hydrogen sulfide (H₂S) are also generated by the endothelium and can also affect vascular tone and a crosstalk may exist between H₂S and NO. We therefore investigated...

article

Hydrogen sulfide: A novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta

Gunay Yetik-Anacak, Gulnur Sevin, Ozge Ozzayım, Mehmet Vehbi Dereli, more

Vascular Pharmacology > 2016 > 87 > C > 76-82

Reactive oxygen species (ROS) decreases bioavailability of nitric oxide (NO) and impairs NO-dependent relaxations. Like NO, hydrogen sulfide (H₂S) is an antioxidant and vasodilator; however, the effect of ROS on H₂S-induced relaxations is unknown. Here we investigated whether ROS altered the effect of H₂S on vascular tone in mouse aorta and determined whether resveratrol (RVT) protects it via H₂S...

article

Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosum

Günay Yetik-Anacak, Aycan Dikmen, Ciro Coletta, Emma Mitidieri, more

Pharmacological Research > 2016 > 113 > PA > 38-43

Erectile dysfunction (ED) is considered as a marker for cardiovascular diseases. Nitric oxide (NO) deficiency is the major cause of erectile dysfunction (ED). The role of hydrogen sulfide (H₂S) in erection has recently been recognized and is receiving attention as a pharmacological target. Several studies have focused on the effect of H₂S on NO-dependent relaxation, but the role of NO on H₂S in penile...

article

Resveratrol Stimulates Hydrogen Sulfide (H₂S) Formation to Relax Murine Corpus Cavernosum

Gunay Yetik‐Anacak, Mehmet V. Dereli, Gulnur Sevin, Ozge Ozzayım, more

The Journal of Sexual Medicine > 12 > 10 > 2004 - 2012

IntroductionResveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H₂S) is a potent vasodilator and neuromodulator generated in corpus cavernosum. AimsWe investigated whether RVT caused the relaxation of mice corpus cavernosum...

article

Hydrogen sulfide is involved in the antioxidant effects of taurine

Gunay Yetik Anacak, Mehmet Vehbi Dereli, Ozge Ozzayim, Gulnur Sevin

Nitric Oxide > 2015 > 47 > Supplement > S55-S56

article

The role of hydrogen sulfide on the regulation of vascular tonus in mice aorta and relation with taurine

Gulnur Sevin, Ozge Ozzayim, Mehmet Vehbi Dereli, Gunay Yetik Anacak

Nitric Oxide > 2015 > 47 > Supplement > S56

article

Caveolae depletion contributes to impaired relaxation induced by hydrogen sulfide in isolated human saphenous vein

Selin Yamakoğlu, F. İlkay Alp Yildirim, Günay Yetìk Anacak, Önder Teskìn, more

Nitric Oxide > 2015 > 47 > Supplement > S24-S25

article

P10 New mechanism for the beneficial effect of sildenafil on erectile function: H2S

Aycan Dikmen, Roberta d’Emmanuele di Villa Bianca, Emma Mitidieri, Erminia Donnarumma, more

Nitric Oxide > 2013 > 31 > Supplement 2 > S38

It has been extensively demonstrated that hydrogen sulfyde (H ₂ S) is implicated is several physiological and pathological conditions (J Mol Med, 2012 Mar;90(3):255–63). In particular, it has been shown that H ₂ S causes relaxation in human penile tissues (Proc Natl Acad Sci USA, 2009 Mar 17;106(11):4513–8) and inhibits phosphodiesterase (PDE) activity in vessels (ATVB 2010, Oct;30(10):1998–2004)...

article

Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure

Günay Yetik Anacak, Levent Üstünes, Ozlem Yilmaz Dilsiz, Adviye Ergul

Vascular Pharmacology > 2010 > 53 > 5-6 > 193-199

The antiatherosclerotic effect of lacidipine has been attributed to its actions on cholesterol levels, lipid metabolism or oxidant stress in advanced disease. The purpose of the present experiments was to examine whether lacidipine is protective of intimal thickening and vascular dysfunction in early atherosclerosis in the absence of the hypertension and hypercholesterolemia. A second goal was to...

article

Nitric oxide and the endothelium: History and impact on cardiovascular disease

Gunay Yetik-Anacak, John D. Catravas

Vascular Pharmacology > 2006 > 45 > 5 > 268-276

There are few discoveries with the magnitude of the impact that NO has had on biology during the 25 years since its discovery. There is hardly a disease today not associated with altered NO homeostasis. In fact, despite numerous other endothelial functions, endothelial dysfunction has become synonymous with reduced biological activity of NO.Translating the preclinical discoveries in NO biology to...

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Keywords

HYDROGEN SULFIDE (4)
NITRIC OXIDE (4)
CORPUS CAVERNOSUM (3)
ENOS (2)
ERECTILE DYSFUNCTION (2)
RESVERATROL (2)
(±)-GOSSYPOL (1)
5-HT SENSITIVITY (1)
ANTI-ANGIOGENESIS (1)
AORTA (1)
BOLDINE (1)
CALCIUM CHANNELS (1)
CARDIOVASCULAR DISEASE (1)
COLLAR-INDUCED ATHEROSCLEROSIS (1)
ENDOTHELIUM (1)
ERECTILE FUNCTION (1)
HUMAN UMBILICAL VEIN ENDOTHELIAL CELL (HUVEC) (1)
HYDROGEN SULPHIDE (1)
INTIMAL THICKENING (1)
L-NNA (1)
LACIDIPINE (1)
METABOLIC SYNDROME (1)
MMP-9 (1)
MOUSE CAROTID ARTERY (1)
OXIDATIVE STRESS (1)
PHOSPHODIESTERASE 5 INHIBITOR (1)
PRANGOS (1)
RABBIT CAROTID ARTERY (1)
RELAXATION (1)
RESISTIN (1)
SURAMIN (1)
VASCULAR REACTIVITY (1)
VASCULAR RELAXATION (1)
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Elsevier (9)
Wiley (3)
Springer (1)

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