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Since the first identification of interleukin (IL)-6 as a myeloma cell growth factor by Dr. Kawano’s and Dr. Klein’s groups 14 years ago, numerous studies have emphasized its major roles in the emergence of malignant plasma cells in vivo and in the generation of normal plasma cells. Four transcription factors control B-cell differentiation into plasma cells. The B-cell transcription factor pax-5 is...
Mycloma cells absolutely require interleukin-6 (IL-6) for growing in vivo in patients with multiple mycloma and exogenous IL-6-dependentmycloma cell lines have been reproducibly obtained. In this study we show a dramatic up-regulation of the IL-6 receptor (gp80 chain) gene expression in mycloma cell lines following the removal of exogenous IL-6. Such a regulation was also known to occur in IL-6-deprived...
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