Search results for: S. Cianchetti

Items from 1 to 9 out of 9 results

article

C0107: Leptin Induces the Generation of Microparticles by Human Mononuclear Cells

S. Petrini, T. Neri, S. Lombardi, C. Balia, more

Thrombosis Research > 2014 > 133 > Supplement 3 > S93

article

Are sputum eosinophil cationic protein and eosinophils differently associated with clinical and functional findings of asthma?

S. Cianchetti, E. Bacci, L. Ruocco, T. Pavia, more

Clinical & Experimental Allergy > 44 > 5 > 673 - 680

BackgroundSputum eosinophil counts and eosinophil cationic protein (ECP) levels are usually increased in asthmatic patients. The correlation between sputum eosinophils or ECP and clinical findings of asthma has been previously investigated but many of these studies have been performed on small samples of asthmatic patients, considering only few clinical indices and often including patients on oral...

article

The mechanisms of nadroparin‐mediated inhibition of proliferation of two human lung cancer cell lines

Y. Carmazzi, M. Iorio, C. Armani, S. Cianchetti, more

Cell Proliferation > 45 > 6 > 545 - 556

ObjectivesClinical data suggest that heparin treatment improves survival of lung cancer patients, but the mechanisms involved are not fully understood. We investigated whether low molecular weight heparin nadroparin, directly affects lung cancer cell population growth in conventionally cultured cell lines. Materials and methodsA549 and CALU1 cells’ viability was assessed by MTT and trypan blue exclusion...

article

PO-83 Nadroparin inhibits A549 human lung adenocarcinoma cell proliferation through down-regulation of cyclin B1 and G2/M phase cell-cycle arrest

Y. Carmazzi, M. Iorio, F. Raggi, S. Cianchetti, more

Thrombosis Research > 2010 > 125 > Supplement 2 > S188

article

Predictors of symptom recurrence after low-dose inhaled corticosteroid cessation in mild persistent asthma

M. Tonelli, E. Bacci, F.L. Dente, M.L. Bartoli, more

Respiratory Medicine > 2006 > 100 > 4 > 622-629

In order to identify predictors of recurrence of asthma symptoms after withdrawal of therapy in mild persistent asthmatics, asymptomatic on low-dose inhaled corticosteroids (ICS), we studied 87 asthmatic patients regularly treated with ICS for at least 6 months. At the enrollment visit (T1), 71 on ICS were asymptomatic over the past 3 months and discontinued asthma treatment. Symptoms and PEF were...

article

One week treatment with salmeterol does not prevent early and late asthmatic responses and Sputum eosinophilia induced by allergen challenge in asthmatics

F.L. Dente, E. Bacci, M.L. Bartoli, S. Cianchetti, more

Pulmonary Pharmacology & Therapeutics > 2004 > 17 > 3 > 147-153

Salmeterol is an effective long-acting β ₂ -agonist bronchodilator, able to inhibit, as a single dose, asthmatic responses induced by several stimuli including allergen, and the subsequent increase in sputum eosinophilia. Aim of the present study was to investigate whether these effects of salmeterol persisted after 1 week of continuous treatment, or whether a loss of the bronchoprotective...

article

Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation

M.L. Bartoli, E. Bacci, S. Carnevali, S. Cianchetti, more

Respiratory Medicine > 2004 > 98 > 2 > 184-193

In the aim to evaluate the relationship between sputum eosinophil percentages and eosinophil cationic protein (ECP) concentrations, as markers of airway inflammation, and different levels of asthma severity, we examined 223 patients consecutively observed in our asthma clinic. Diagnosis of asthma was made according to internationally accepted criteria. Asthma severity was evaluated according to frequency...

article

Fifty μg b.i.d. of inhaled fluticasone propionate (FP) are effective in stable asthmatics previously treated with a higher dose of FP

D. GIANNINI, A. DI FRANCO, M. TONELLI, M. L. BARTOLI, more

Respiratory Medicine > 2003 > 97 > 5 > 463-467

Twenty-seven subjects with moderate asthma at the time of diagnosis, well controlled under regular fluticasone propionate (FP) (250 μg b.i.d.) for 6 months at least, were randomized to receive in double-blind fashion: FP 125 μg b.i.d. (Group 1) or FP 50 μg b.i.d. (Group 2) or placebo (Group 3) for 3 months or until symptom recurrence. Daily symptom score and peak expiratory flow were monitored. At...

article

Leukocyte counts in hypertonic saline-induced sputum in subjects with occupational asthma

A.Di Franco, B. Vagaggini, E. Bacci, M.L. Bartoli, more

Respiratory Medicine > 1998 > 92 > 3 > 550-557

We measured markers of eosinophilic inflammation in the blood and in the sputum induced by hypertonic saline (HS) inhalation of 24 subjects with occupational asthma who were still exposed to high molecular weight compounds (HMWCs, n=8) or to low molecular weight compounds (LMWCs, n=16); all subjects were symptomatic and showed bronchial hyperresponsiveness to methacholine at the time of study. Sputum...

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