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Dysregulated Ca 2+ homeostasis likely contributes to the etiology of inflammatory bowel disease–associated loss of bone mineral density. Experimental colitis leads to decreased expression of Klotho, a protein that supports renal Ca 2+ reabsorption by stabilizing the transient receptor potential vanilloid 5 (TRPV5) channel on the apical membrane of distal tubule epithelial cells.Colitis...
NHE3 is a target of inhibition by proinflammatory cytokines and pathogenic bacteria, an event contributing to diarrhea in infectious and idiopathic colitis. In mice, NHE3 deficiency leads to mild diarrhea, increased intestinal expression of interferon (IFN)-γ, and distal colitis, suggesting its role in epithelial barrier homeostasis. Our aim was to investigate the role of NHE3 in maintaining mucosal...
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