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Cabazitaxel plus prednisone has significant activity in patients with chemotherapy-naïve and pretreated metastatic castration-resistant prostate cancer (mCRPC). Mitoxantrone has antitumor activity in mCRPC and nonoverlapping mechanism of action and toxicity profile.To establish the maximally tolerated dose of the combination of cabazitaxel, mitoxantrone, and prednisone.Patients with chemotherapy-naïve...