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Cells in target organs such as liver do not generally incorporate tetrahydrobiopterin (BH 4 ) in its fully reduced form. Instead, they transiently take up BH 4 from the extracellular fluid, instantaneously oxidize it and then expel virtually all of it. However, a small but stable accumulation of BH 4 was observed after BH 4 administration to the cell cultures. This...