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Purpose of Review Transjugular intrahepatic portosystemic shunt (TIPS) placement is a well-established interventional radiology procedure for treating sequelae of portal hypertension involving shunting portal blood flow to the hepatic vein bypassing the liver through a stent graft. Creating a TIPS can be a complex and radiation-intensive procedure due to the technically challenging step of cannulating...
We present a novel class of ultrasound (US) contrast agents, which enable de novo production of echogenic O2 microbubbles (MBs) in vivo in regions with elevated hydrogen peroxide (H2O2). The agent is a 200 nm silica shell nanoparticle loaded with catalase (catSHEL) that catalyzes H2O2 into water (H2O) and oxygen (O2). Importantly, this reactive process produces O2 MBs visible during US imaging. We...
We present a new class of ultrasound molecular imaging agents that extend upon the design of micromotors that are designed to move through fluids by catalyzing hydrogen peroxide (H 2 O 2 ) and propelling forward by escaping oxygen microbubbles. Micromotor converters require 62 mm of H 2 O 2 to move – 1000-fold higher than is expected in vivo. Here, we aim to prove that...
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