Search results for: Narayan Bhattarai

Items from 1 to 20 out of 26 results

article

Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofiber for tissue engineering applications

Nava P. Rijal, Udhab Adhikari, Shalil Khanal, Devdas Pai, more

Materials Science and Engineering: B > 2018 > 228 > C > 18-27

The ability to produce composite nanofibers of inorganic particles and synthetic polymers represents a significant advancement in the development of composite materials for potential biomedical applications. In this study, composite nanofibers of magnesium oxide (MgO), poly(ε-caprolactone) (PCL) and chitosan (CS) with diameters in the range of 0.7–1.3 µm were fabricated by electrospinning their blend...

article

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification

Andrey P. Tikunov, Yoo-Sik Shim, Narayan Bhattarai, Scott Q. Siler, more

Toxicology in Vitro > 2017 > 45 > P1 > 119-127

Real-time dose-response curves for fructose have been non-invasively determined in primary rat hepatocyte alginate spheroids cultured in a NMR-compatible fluidized-bed bioreactor. Using ¹³C–labeled glucose and glycine culture medium, fructose dose was compared to glucose uptake and glycogen synthesis rate using ¹³C NMR spectroscopy, and to ATP and fructose-1-phosphate concentration using ³¹P NMR spectroscopy...

article

Synthesis and characterization of magnesium gluconate contained poly(lactic-co-glycolic acid)/chitosan microspheres

Shekh M. Rahman, Christopher Mahoney, Jagannathan Sankar, Kacey G. Marra, more

Materials Science & Engineering B > 2016 > 203 > Complete > 59-66

The goal of this study was to fabricate and investigate the chitosan coated poly(lactic-co-glycolic acid) (PLGA) microspheres for the development of controlled release magnesium delivery system. PLGA based microspheres are ideal vehicles for many controlled release drug delivery applications. Chitosan is a naturally occurring biodegradable and biocompatible polysaccharide, which can coat the surface...

article

Poly(ε‐caprolactone)/keratin‐based composite nanofibers for biomedical applications

Angela Edwards, David Jarvis, Tracy Hopkins, Sarah Pixley, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 103 > 1 > 21 - 30

Keratin‐based composite nanofibers have been fabricated by an electrospinning technique. Aqueous soluble keratin extracted from human hair was successfully blended with poly(ε‐caprolactone) (PCL) in different ratios and transformed into nanofibrous membranes. Toward the potential use of this nanofibrous membrane in tissue engineering, its physicochemical properties, such as morphology, mechanical...

article

Enhanced bone tissue formation by alginate gel‐assisted cell seeding in porous ceramic scaffolds and sustained release of growth factor

Stephen J. Florczyk, Matthew Leung, Soumen Jana, Zhensheng Li, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 100A > 12 > 3408 - 3415

Increasing cell seeding efficiency in a tissue engineering construct can enhance cellular activity and tissue formation in vivo. Here, we demonstrate the use of alginate gel as a secondary phase material in 3D porous β‐tricalcium phosphate scaffolds to improve cell seeding and provide controlled release of growth factors for bone tissue engineering. Cells were seeded in scaffolds in three ways: conventional...

article

Fabrication and cellular compatibility of aligned chitosan–PCL fibers for nerve tissue regeneration

Ashleigh Cooper, Narayan Bhattarai, Miqin Zhang

Carbohydrate Polymers > 2011 > 85 > 1 > 149-156

The ability to produce aligned sub-micron fibers may open new avenues for the development of scaffolds for application in tissue engineering and regenerative medicine. An area of particular interest is functional restoration of damaged or diseased nerves where the aligned fibers serve to support cell adhesion and proliferation, and guide neurite outgrowth in the direction of fiber orientation. In...

article

Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma

Forrest M. Kievit, Omid Veiseh, Chen Fang, Narayan Bhattarai, more

ACS Nano > 2010 > 4 > 8 > 4587 - 4594

article

PEG-Mediated Synthesis of Highly Dispersive Multifunctional Superparamagnetic Nanoparticles: Their Physicochemical Properties and Function In Vivo

Conroy Sun, Kim Du, Chen Fang, Narayan Bhattarai, more

ACS Nano > 2010 > 4 > 4 > 2402 - 2410

article

Chitosan-based hydrogels for controlled, localized drug delivery

Narayan Bhattarai, Jonathan Gunn, Miqin Zhang

Advanced Drug Delivery Reviews > 2010 > 62 > 1 > 83-99

Hydrogels are high-water content materials prepared from cross-linked polymers that are able to provide sustained, local delivery of a variety of therapeutic agents. Use of the natural polymer, chitosan, as the scaffold material in hydrogels has been highly pursued thanks to the polymer's biocompatibility, low toxicity, and biodegradability. The advanced development of chitosan hydrogels has led to...

article

Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta Raj Bhattarai, Santosh Aryal, Remant Bahadur K.C., Narayan Bhattarai, more

Materials Science & Engineering C > 2008 > 28 > 1 > 64-69

This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study...

article

Hydrophobically modified chitosan/gold nanoparticles for DNA delivery

Shanta Raj Bhattarai, Remant Bahadur K.C., Santosh Aryal, Narayan Bhattarai, more

Journal of Nanoparticle Research > 2008 > 10 > 1 > 151-162

Present study dealt an application of modified chitosan gold nanoparticles (Nac-6-Au) for the immobilization of necked plasmid DNA. Gold nanoparticles stabilized with N-acylated chitosan were prepared by graft-onto approach. The stabilized gold nanoparticles were characterized by different physico-chemical techniques such as UV-vis, TEM, ELS and DLS. MTT assay was used for in vitro cytotoxicity of...

article

Stabilization of gold nanoparticles by thiol functionalized poly(ɛ-Caprolactone) for the labeling of PCL biocarrier

Santosh Aryal, Remant Bahadur K.C., Narayan Bhattarai, Byoung Min Lee, more

Materials Chemistry and Physics > 2006 > 98 > 2-3 > 463-469

Polymer terminated by 2-(2,4-dinitrophenylsulfanyl) ethanol was synthesized by ring opening bulk polymerization of ɛ-Caprolactone initiated by the reaction product of aluminum isopropoxide and 2-(2,4-dinitrophenylsulfenyl) ethanol. The corresponding thiolyated poly(ɛ-Caprolactone) (PCL) was obtained after removal of protecting group under slightly basic condition. Both of PCL end capped by protected...

article

Study of electrolyte induced aggregation of gold nanoparticles capped by amino acids

Santosh Aryal, Remant Bahadur K.C., Narayan Bhattarai, Chul Ki Kim, more

Journal of Colloid And Interface Science > 2006 > 299 > 1 > 191-197

This work reports the electrolyte induced aggregation of gold nanoparticles directly conjugated to amino acid by chemical reduction in aqueous solution. The study was focused on three different classes of amino acids depending on the nature of α substituent, viz. l-cysteine, l-leucine, and l-asparagine. The band broadening and the red shift of surface plasmon band with increase in flocculation parameter...

article

Ceramic modification of N-acylated chitosan stabilized gold nanoparticles

K.C. Remant Bahadur, Santosh Aryal, Narayan Bhattarai, Hak Yong Kim

Scripta Materialia > 2006 > 54 > 12 > 2029-2034

Hydroxyapatite (HAp) [Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ] nanocrystals of controlled geometry were chemically fabricated using N-acylated chitosan stabilized gold nanoparticles (Nac-6-Au) as a matrix and characterized by various physico-chemical techniques. Results showed that the Nac-6-Au played a key role in inducing and directing the growth of HAp nanocrystals.

article

Novel block copolymer (PPDO/PLLA-b-PEG): Enhancement of DNA uptake and cell transfection

Shanta Raj Bhattarai, Ho-Keun Yi, Narayan Bhattarai, Pyoung Han Hwang, more

Acta Biomaterialia > 2006 > 2 > 2 > 207-212

The cationic lipid mediated uptake of plasmid DNA by cells in monolayer culture was significantly enhanced with an aqueous solution of the block copolymer poly(p-dioxanone-co-l-lactide)-b-poly(ethylene glycol) (PPDO/PLLA-b-PEG). Plasmid uptake studies with DNA encoding the β-galactosidase gene and cytotoxicity evaluations were performed on MCF-7, NIH 3T3 and CT-26 cell lines. Transfection yields and...

article

Spectroscopic identification of SAu interaction in cysteine capped gold nanoparticles

Santosh Aryal, Remant B.K.C., N. Dharmaraj, Narayan Bhattarai, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2006 > 63 > 1 > 160-163

This study deals with the synthesis of cysteine capped gold nanoparticles with an average size of 12nm by borohydride reduction and spectroscopic identification of SAu interaction. We have studied the interaction of thiol with gold nanoparticles in aqueous medium by employing UV–vis, Raman, NMR, and FT-IR spectroscopy. The shifting of gold plasmon resonance in the UV–vis spectra shows the stabilization...

article

Mechanical behaviors and characterization of electrospun polysulfone/polyurethane blend nonwovens

Dong Il Cha, Kwan Woo Kim, Gong Hee Chu, Hak Yong Kim, more

Macromolecular Research > 2006 > 14 > 3 > 331-337

In the present study we investigated the relationship between the morphology and mechanical properties of electrospun polysulfone (PSF)/polyurethane (PU)|blend nonwovens, by using the electrospinning process to prepare three types of electrospun nonwovens: PSF, PU and PSF/PU blends. The viscosity, conductivity and surface tension of the polymer solutions, were measured by rheometer, electrical conductivity...

article

Electrospun chitosan-based nanofibers and their cellular compatibility

Narayan Bhattarai, Dennis Edmondson, Omid Veiseh, Frederick A. Matsen, more

Biomaterials > 2005 > 26 > 31 > 6176-6184

Chitosan-based nanofibers with an average fiber diameter controllable from a few microns down to ∼40nm and a narrow size distribution were fabricated by electrospinning solutions containing chitosan, polyethylene oxide (PEO), and Triton X-100™. Rheological study showed a strong dependence of spinnability and fiber morphology on solution viscosity and thus on chitosan-to-PEO ratio. The nanofibers can...

article

Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas

Omid Veiseh, Conroy Sun, Jonathan Gunn, Nathan Kohler, more

Nano Letters > 2005 > 5 > 6 > 1003 - 1008

article

PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release

Narayan Bhattarai, Hassna R. Ramay, Jonathan Gunn, Frederick A. Matsen, more

Journal of Controlled Release > 2005 > 103 > 3 > 609-624

Thermosensitive polymer hydrogels that undergo a sol-to-gel transition in response to temperature changes are of great interest in therapeutic delivery and tissue engineering as injectable depot systems. A chitosan-based, injectable thermogel was prepared by grafting an appropriate amount of PEG onto the chitosan backbone and studied for drug release in vitro using bovine serum albumin (BSA) as a...

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Search results for: Narayan Bhattarai

Magnesium oxide-poly(ε-caprolactone)-chitosan-based composite nanofiber for tissue engineering applications

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification

Synthesis and characterization of magnesium gluconate contained poly(lactic-co-glycolic acid)/chitosan microspheres

Poly(ε‐caprolactone)/keratin‐based composite nanofibers for biomedical applications

Enhanced bone tissue formation by alginate gel‐assisted cell seeding in porous ceramic scaffolds and sustained release of growth factor

Fabrication and cellular compatibility of aligned chitosan–PCL fibers for nerve tissue regeneration

Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma

PEG-Mediated Synthesis of Highly Dispersive Multifunctional Superparamagnetic Nanoparticles: Their Physicochemical Properties and Function In Vivo

Chitosan-based hydrogels for controlled, localized drug delivery

Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Hydrophobically modified chitosan/gold nanoparticles for DNA delivery

Stabilization of gold nanoparticles by thiol functionalized poly(ɛ-Caprolactone) for the labeling of PCL biocarrier

Study of electrolyte induced aggregation of gold nanoparticles capped by amino acids

Ceramic modification of N-acylated chitosan stabilized gold nanoparticles

Novel block copolymer (PPDO/PLLA-b-PEG): Enhancement of DNA uptake and cell transfection

Spectroscopic identification of SAu interaction in cysteine capped gold nanoparticles

Mechanical behaviors and characterization of electrospun polysulfone/polyurethane blend nonwovens

Electrospun chitosan-based nanofibers and their cellular compatibility

Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas

PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release

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