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This report describes age-related alterations of dendritic cells (DC) distribution in nude athymic mice in vivo and reversal of certain age-dependent defects by an in vivo administration of hematopoietic growth factor FLT3 ligand (FLT3L). There are decreased percentages of CD11c + DC in the bone marrow and spleen and a reduced expression of MHC class II and CD86 molecules on DC in old nude...
FLT3 ligand (FL) is a recently described hematopoietic growth factor that stimulates the proliferation and differentiation of hematopoietic progenitors. We have investigated the effect of FL on murine hematopoiesis and dendritic cell (DC) generation and accumulation in lymphoid tissues and liverin vivoandin vitroevaluating the morphologic, phenotypic, and functional characteristics of these DC. We...
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