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Development of molecular probes holds great promise for early diagnosis of aggressive prostate cancer. Here, 2‐[3‐(1,3‐dicarboxypropyl) ureido] pentanedioic acid (DUPA)‐conjugated ligand and bis‐isoindigo‐based polymer (BTII) are synthesized to formulate semiconducting polymer nanoparticles (BTII‐DUPA SPN) as a prostate‐specific membrane antigen (PSMA)‐targeted probe for prostate cancer imaging in...
In this article, we described a new computational framework to construct “Super Gene Sets”-Pathways, Annotated list, and Gene signatures (PAGs), regulatory (r-type) PAG-PAG relationships. To construct PAGs, we aggregate singleton PAGs (sPAGs) upstream/downstream of a common shared multi-gene PAG (mPAGs). Then, we iteratively remove a member gene to calculate its Cohesion Coefficient (CoCo), which...
Objectives. Stress-related exacerbation of interstitial cystitis (IC) symptoms has frequently been reported. Previous research has found stress-related IC symptom exacerbation in an experimental model. However, this relationship has not been objectively examined with daily life stressors. We used a prospective daily symptom diary method to investigate the relationships among stress and bladder symptoms...
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