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Clinical evidences reveal the anti-pruritic effect of Botulinum toxin type A (BoNT/A). BoNT/A inhibits the release of acetylcholine as well as some other substances, which may be involved in pruritus. The present study investigated the effect of subcutaneous administration of BoNT/A on experimentally induced itch by histamine in human skin.Fourteen healthy male volunteers (26.3±2.6 years) received...