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The G-protein coupled metabotropic glutamate receptors (mGluRs) play important roles in the tune regulation of fast synaptic excitatory transmission in the brain. Eight genes encoding mGluRs have been identified in mammals, and some have already been characterized in nematodes and insects. Based on their sequence homology, transduction mechanism and pharmacology, mGluRs can be classified into 3...
Mammalian metabotropic glutamate receptors (mGluRs) can be classified into three groups based on their sequence homology, transduction mechanism and pharmacology. Although both group-II and group-III mGluRs inhibit adenylyl cyclase, their G-protein coupling selectivity is different as shown with the use of the promiscuous G alpha subunits G15 and G16 and the chimeric Gq subunits that possess the...
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