Search results for: Rajeshwar Nath Srivastava

Items from 1 to 8 out of 8 results

article

Identifying the role of ASPN and COMP genes in knee osteoarthritis development

Abhishek Mishra, Sachin Awasthi, Saloni Raj, Priya Mishra, more

Journal of Orthopaedic Surgery and Research > 2019 > 14 > 1 > 1-9

Background Osteoarthritis (OA) is a common cause of musculoskeletal disability among elders and is characterized by late-onset degeneration of articular cartilage. OA affects various joints, commonly hand, knee, and hip, with clinical features that are unique to each joint. This study was initiated to identify and evaluate the role of the ASPN and COMP genes in the development of knee OA. Methods...

article

Significance of methylation status of MASPIN gene and its protein expression in prognosis of gallbladder cancer

Kavita Baghel, Hasan Raza Kazmi, Abhijit Chandra, Saloni Raj, more

Asia‐Pacific Journal of Clinical Oncology > 15 > 5 > e120 - e125

Aim We investigated prognostic significance of methylation status of MASPIN gene and its protein expression in normal subjects, cholelithiasis and gallbladder cancer (GBC) patients. Methods MASPIN protein expression and its promoter methylation in gallbladder tissue of cholelithiasis (n = 36), GBC (n = 46) and controls (n = 25) were investigated. Clinicopathological parameters and prognosis of...

article

CYR61—An angiogenic biomarker to early predict the impaired healing in diaphyseal tibial fractures

Sabir Ali, Ajai Singh, Abbas Ali Mahdi, Rajeshwar Nath Srivastava

Journal of Orthopaedic Translation > 2017 > 10 > C > 5-11

Angiogenesis is a prerequisite for fracture repair, whereas insufficient blood supply is likely to result in impaired healing. In the present study, we aimed to determine the correlation of simple tibial fracture healing outcome with serial estimation of CYR61 expressions in the early phase of healing.In total, 107 adult fractured patients and 97 healthy controls were analysed. Peripheral blood samples...

article

Proton NMR metabolic profiling of CSF reveals distinct differentiation of meningitis from negative controls

Tanushri Chatterji, Suruchi Singh, Manodeep Sen, Ajai Kumar Singh, more

Clinica Chimica Acta > 2017 > 469 > C > 42-52

Cerebrospinal fluid (CSF) is an essential bio-fluid of the central nervous system (CNS), playing a vital role in the protection of CNS and performing neuronal function regulation. The chemical composition of CSF varies during onset of meningitis, neurodegenerative disorders (positive controls) and in traumatic cases (negative controls).The study design was broadly categorized into meningitis cases,...

article

TNF-α, IL-6, and IL-8 Cytokines and Their Association with TNF-α-308 G/A Polymorphism and Postoperative Sepsis

Kavita Baghel, Rajeshwar Nath Srivastava, Abhijit Chandra, Sudhir K. Goel, more

Journal of Gastrointestinal Surgery > 2014 > 18 > 8 > 1486-1494

Introduction Early prediction of postoperative sepsis remains an enormous clinical challenge. Association of TNF-α-308 G/A polymorphism with sepsis remains controversial. We, therefore, investigated this polymorphism with serum levels of cytokines TNF-α, IL-6, and IL-8 in relation to development of sepsis following major gastrointestinal surgery. Methods Two hundred and thirty-nine patients undergoing...

article

Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial

Divya Sanghi, Abhishek Mishra, Amar Chandra Sharma, Ajai Singh, more

Clinical Orthopaedics and Related Research® > 2013 > 471 > 11 > 3716-3717

(Re: Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN. Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial [published online ahead of print Aug. 1, 2013]. Clin Orthop Relat Res. Doi: 10.1007/s11999-013-3201-6 .) The authors certify that they, or any members of their immediate families, have no funding or commercial associations (eg, consultancies,...

article

Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial

Divya Sanghi, Abhishek Mishra, Amar Chandra Sharma, Ajai Singh, more

Clinical Orthopaedics and Related Research® > 2013 > 471 > 11 > 3556-3562

Background Animal, epidemiologic, and human clinical studies suggest a putative role for vitamin D in osteoarthritis (OA). Inadequate sunlight exposure and lower serum levels of 25(OH)D appear in some reports to be associated with an increased risk for progression of knee OA. Questions/purposes We asked whether treatment with vitamin D would (1) reduce knee pain (WOMAC and VAS), (2) improve function...

article

Is radiology a determinant of pain, stiffness, and functional disability in knee osteoarthritis? A cross-sectional study

Divya Sanghi, Sachin Avasthi, Abhishek Mishra, Ajai Singh, more

Journal of Orthopaedic Science > 2011 > 16 > 6 > 719-725

Background and purposes Discordance between clinical and radiological profiles in knee osteoarthritis has been reported. We hypothesized that the discordance could be due to limited radiological variables studied. This study essentially analyzed many more radiological features than previous studies in order to seek an association between clinical and radiographic features. Methods One hundred and...

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Keywords

ANGIOGENESIS (1)
BIOMARKER (1)
CASE–CONTROL (1)
CEREBROSPINAL FLUID (1)
CYR61 (1)
CYTOKINES (1)
FRACTURE (1)
GALLBLADDER CANCER (1)
GENE (1)
GENE EXPRESSION (1)
GENETIC POLYMORPHISM (1)
KNEE OSTEOARTHRITIS (1)
MASPIN EXPRESSION (1)
MENINGITIS (1)
METABOLIC PROFILING (1)
METHYLATION (1)
NEGATIVE CONTROLS (1)
NMR SPECTROSCOPY (1)
POSITIVE CONTROLS (1)
PROGNOSIS (1)
RESTRICTION FRAGMENT LENGTH POLYMORPHISM (1)
SEPSIS (1)
SURVIVAL (1)
TUMOR NECROSIS FACTOR (1)
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Springer (5)
Elsevier (2)
Wiley (1)

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Search results for: Rajeshwar Nath Srivastava

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