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Recent studies have demonstrated that epidermal growth factor receptor (EGFR) mutations are a predictive molecular marker of tumor response to gefitinib treatment in non-small-cell lung cancer (NSCLC). Early studies of EGFR mutations have been analyzed by direct sequencing with surgically resected specimens. However, it is often difficult to obtain sufficient and tumor-enriched tissue specimens from...
Objective: Docetaxel and carboplatin (DC) have demonstrated activity as radiation sensitizers in pre-clinical studies. The aim of this phase II study was to evaluate the efficacy and toxicity of DC with concurrent thoracic radiation therapy (TRT) followed by consolidation chemotherapy with DC for stage III unresectable non-small cell lung cancer (NSCLC). Patients and methods: Thirty-three previously...
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