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Congenital central hypoventilation syndrome (CCHS) children show cognitive and affective deficits, in addition to state-specific loss of respiratory drive. The caudate nuclei serve motor, cognitive, and affective roles, and show structural deficits in CCHS patients, based on gross voxel-based analytic procedures. However, the magnitude and regional sites of caudate injury in CCHS are unclear. We assessed...
We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer's disease (AD) Neuroimaging Initiative, combining AdaBoost with a novel model, the auto context model (ACM). Trained on 21 hand-labeled segmentations, ACM created binary hippocampus maps in 100 controls, 200 with mild cognitive impairment (MCI), and 100 AD subjects, (age: 75.8+/-6.6SD). A radial atrophy mapping technique...
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