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Purpose We present a new Label free quantitative imaging of small molecules in order to investigate their roles in ophthalmic disorders (toxicity, inflammation)
Methods Quantitative Mass Spectrometry imaging has been developed and applied to ophthalmology to assess the distribution and quantification of Benzalkonium chloride (BAK) compound in specific areas of the eye after instillation. This method...
MALDI-TOF MS (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry) imaging is used to characterize novel lipid implants allowing for controlled drug delivery. Importantly, this innovative technique provides crucial information on the inner structure of the implants before and after exposure to the release medium and does not require the addition of marker substances. Implants...
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