Search results for: Chae Woong LIM

Items from 1 to 20 out of 29 results

article

Experimental infection of dogs with severe fever with thrombocytopenia syndrome virus: Pathogenicity and potential for intraspecies transmission

Seok‐Chan Park, Jun Young Park, Jin Young Choi, Byungkwan Oh, more

Transboundary and Emerging Diseases > 69 > 5 > 3090 - 3096

Severe fever with thrombocytopenia syndrome (SFTS) is caused by infection with Dabie bandavirus [formerly SFTS virus (SFTSV)] and is an emerging zoonotic disease. Dogs can be infected with SFTSV, but its pathogenicity and transmissibility have not been fully elucidated. In experiment 1, immunocompetent dogs were intramuscularly inoculated with SFTSV. In experiment 2, immunosuppressed dogs (immunosuppressed...

article

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

Jong‐Won Kim, Daram Yang, Hyeneui Jeong, Il Song Park, more

Phytotherapy Research > 33 > 5 > 1538 - 1550

Acute liver injury (ALI) is a life‐threatening clinical syndrome. Long‐lasting liver injury can lead to chronic hepatic inflammation and fibrogenic responses. Zerumbone (ZER), the main constituent of rhizomes of Zingiber zerumbet Smith, has a variety of functions including anticancer activity. We investigated the role of ZER on the progression of hepatotoxin‐induced liver injury. Single or repeated...

article

Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced lipotoxicity and steatohepatitis in vitro

Zixiong Zhou, Jong Won Kim, Jing Zhao, Jing Qi, more

Toxicology in Vitro > 2018 > 52 > C > 33-40

Accumulative evidence showed that cigarette smoke (CS) detrimentally affects the pathogenesis of nonalcoholic steatohepatitis (NASH). The purpose of this study was to evaluate the effects of CS extract (CSE) or total particulate matter (TPM) on the in vitro steatohepatitis model using mouse primary hepatocytes treated with palmitic acid (PA) or PA plus LPS. Increased hepatocellular damage was observed...

article

Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model

Jong Won Kim, Hyuneui Jeong, Myeon-Sik Yang, Chae Woong Lim, more

International Immunopharmacology > 2017 > 48 > C > 126-134

Cornea is an avascular transparent tissue. Ocular trauma caused by a corneal alkali burn induces corneal neovascularization (CNV), inflammation, and fibrosis, leading to vision loss. The purpose of this study was to examine the effects of Zerumbone (ZER) on corneal wound healing caused by alkali burns in mice. CNV was induced by alkali-burn injury in BALB/C female mice. Topical ZER (three times per...

article

Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice

Surim Park, Jong Won Kim, Hyejin Yun, Seong-Jin Choi, more

Toxicology Letters > 2016 > 256 > C > 53-63

Cigarette smoking in adolescents is considered to be a major cause of preventable morbidity and mortality. The purpose of this study is to investigate the role of mainstream cigarette smoke (MSCS) on the progression of nonalcoholic steatohepatitis in adolescents. Three-week-old C57BL/6 mice were fed either a methionine and choline-deficient plus high fat (MCDHF) diet for 6 weeks. Each group was exposed...

article

Developmental competence and cryotolerance of caprine parthenogenetic embryos cultured in chemically defined media

Woo-Jae Choi, Ji-Hyun Lee, Sang-Hee Lee, Soo-Young Yum, more

Theriogenology > 2016 > 86 > 2 > 596-603

In animal reproduction technologies, the in vitro embryo culture system has advanced over the past few decades. However, in vitro cultured embryos still have reduced functional and physiological abilities compared with those from in vivo conditions, and many factors of oviduct and uterine environments have not yet been revealed. Here, we demonstrated the in vitro culture of domestic goat (Capra hircus)...

article

Experimental infection of cows with newly isolated Akabane virus strain (AKAV-7) causing encephalomyelitis

Hyeyeoun Lee, Hansol Jeong, Surim Park, Myeon-Sik Yang, more

Veterinary Research > 2016 > 47 > 1 > 1-12

Akabane virus (AKAV), an arthropod-transmitted bunyavirus, is a major cause of congenital abnormalities and encephalomyelitis in ruminants. In 2010, there was a major outbreak of encephalomyelitis in Korea and fifteen AKAV strains, including AKAV-7, were isolated from cows. To identify the neuropathogenicity of AKAV-7, we performed experimental infection of cows. Six-month-old female Korean Holstein...

article

Nasal immunization with M cell-targeting ligand-conjugated ApxIIA toxin fragment induces protective immunity against Actinobacillus pleuropneumoniae infection in a murine model

Jisang Park, Ki-Weon Seo, Sae-Hae Kim, Ha-Yan Lee, more

Veterinary Microbiology > 2015 > 177 > 1-2 > 142-153

Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia and severe economic loss in the swine industry has been caused by the infection. Therefore, the development of an effective vaccine against the bacteria is necessary. ApxII toxin, among several virulence factors expressed by the bacteria, is considered to be a promising vaccine candidate because ApxII toxin not only...

article

Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury

Yoon Seok Roh, Surim Park, Chae Woong Lim, Bumseok Kim

Digestive Diseases and Sciences > 2015 > 60 > 7 > 2009-2018

Background Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. Aims To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, which expresses the diphtheria toxin receptor under control of the Foxp3 promoter,...

article

Toll‐like receptor 7‐mediated type I interferon signaling prevents cholestasis‐ and hepatotoxin‐induced liver fibrosis

Yoon Seok Roh, Surim Park, Jong Won Kim, Chae Woong Lim, more

Hepatology > 60 > 1 > 237 - 249

Toll‐like receptor 7 (TLR7) signaling predominantly regulates production of type I interferons (IFNs), which has been suggested in clinical studies to be antifibrotic. However, the mechanistic role of the TLR7‐type I IFN axis in liver fibrosis has not been elucidated. In the present study, liver fibrosis was induced in wild‐type (WT), TLR7‐deficient, and IFN‐α/β receptor‐1 (IFNAR1)‐deficient mice...

article

Effects of glass bead size, vortexing speed and duration on Eimeria acervulina oocyst excystation

Jang-Ock Cha, Abul Fatah Shah Muhammad Talha, Chae Woong Lim, Bumseok Kim

Experimental Parasitology > 2014 > 138 > Complete > 18-24

Improved methods for efficient excystation of Eimeria should be developed and standardized for future Eimeria-related studies. Here, the effects of different glass bead sizes (0.5, 1, 2, and 2.5mm), and various vortex speeds (1000, 2000, and 3000rpm) and durations (30s, 1, 3, and 5min) have been examined for Eimeria (E.) acervulina oocyst excystation. At 3000rpm, all glass beads, regardless of size,...

article

Detrimental effects of cement mortar and fly ash mortar on asthma progression

Ara Cho, Hong-Seok Jang, Yoon Seok Roh, Hee Jin Park, more

Environmental Toxicology and Pharmacology > 2013 > 36 > 3 > 1087-1096

Currently, concrete additive materials are used worldwide to improve properties of concrete production and to reduce the total cost of the materials used in the concrete. However, the effects of exposure to various gases emitted from mortar mixed with additive materials are poorly understood. To evaluate the pattern of gas emission from cement mortar and additives, the emission levels of gas including...

article

Differential immune modulation by deoxynivalenol (vomitoxin) in mice

Mohammad Rafiqul Islam, Yoon Seok Roh, Jinho Kim, Chae Woong Lim, more

Toxicology Letters > 2013 > 221 > 2 > 152-163

Mycotoxin deoxynivalenol (DON), a secondary metabolite produced by Fusarium fungi, is a contaminant in wheat, barley, and corn worldwide. It has been suggested that DON exhibits toxicity in various organs. Due to the lack of immunotoxicity data for DON, we investigated the differential immunomodulatory effects of DON in mice. DON was orally administered to female BALB/c mice at a dose of 0, 0.5, or...

article

Immune modulatory effects of the foodborne contaminant citrinin in mice

Mohammad Rafiqul Islam, Yoon-Seok Roh, Ara Cho, Jinho Kim, more

Food and Chemical Toxicology > 2012 > 50 > 10 > 3537-3547

The mycotoxin citrinin can cause mycotoxic nephropathy, cytotoxicity and genotoxicity. To investigate the immune modulatory effects, CTN was orally administered to female BALB/c mice at the dose of 1, 5, or 10mg/kg body weight for 14days, and several immunotoxicity tests were performed. The populations of F4/80 ⁺ cells and CD19 ⁺ cells were significantly decreased in spleen and MLN...

article

3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice

Yoon Seok Roh, Ara Cho, Mohammad Rafiqul Islam, Sung-Dae Cho, more

Toxicology Letters > 2011 > 206 > 2 > 218-228

3,3′-Diindolylmethane (DIM), a major product of indole-3-carbinol derived from vegetables of the genus Brassica, exhibits chemotherapeutic activity and various immune modulatory effects in animal models and in vitro studies. Although extensive studies have only focused on DIM's beneficial effects, the toxic effects of DIM on the immune systems have not been clearly elucidated. The aim of this study...

article

Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis

Sohail EJAZ, Ahmed EJAZ, Amara SOHAIL, Chae Woong LIM

Biomedical and Environmental Sciences > 2010 > 23 > 4 > 305-311

Embryonic movements (EM) and angiogenesis pathways are evolutionarily conserved mechanisms which are essential for proper embryonic development. Deviations in these processes by exposure to cigarette smoke condensate (CSC) may cause vascular and morphogenetic disorders. Using chicken and mouse embryos, we have demonstrated the in vivo effects of CSC on EM, vascular development, and organogenesis...

article

Pollution dilemma in Asian population: CNG and wound healing

Sohail Ejaz, Irina Chekarova, Mukhtar Ahmad, Amir Nasir, more

Environmental Toxicology and Pharmacology > 2009 > 28 > 3 > 323-332

Automobile exhaust constituents contribute significantly to air pollution in urban areas and compressed natural gas (CNG) is considered one of the most promising fuel alternatives for the future. CNG-powered four-stroke engine auto-rickshaws are ubiquitous in South Asian cities as taxi and for commercial transportation. Automotive exhaust contains several toxins, which are overwhelmingly toxic to...

article

Detrimental effects of cigarette smoke constituents on physiological development of extraocular and intraocular structures

Sohail Ejaz, Muhammad Adil, Myong Ho Oh, Syed Muhammad Muneeb Anjum, more

Food and Chemical Toxicology > 2009 > 47 > 8 > 1972-1979

No investigation has yet been accomplished to screen the detrimental effects of cigarette smoke condensate (CSC) and total particular matter solution (TPMS) on embryonic development of extraocular and intraocular structures. In this report, chicken embryo assay was utilized to undermine diverse ocular pathologies produced by exposure of CSC and TPM. Extraocular anomalies triggered after exposure of...

article

Total Particulate Matter and Wound Healing: An in vivo Study with Histological Insights

SOHAIL EJAZ, MUHAMMAD ASHRAF, MUHAMMAD NAWAZ, CHAE WOONG LIM

Biomedical and Environmental Sciences > 2009 > 22 > 4 > 278-287

Wound healing in the skin is a multifarious orchestration of cellular processes and cigarette smoking may be a cause for delayed wound healing. The aim of this study was to investigate the plausible association between exposures of cigarette total particulate matter (TPM) and wound healing. An in vivo wound healing model of mice was established for determination of assorted events of wound healing,...

article

Anti-angiogenic activities associated with exposure of environmental smoke solutions from 2-stroke auto-rickshaw

Sohail Ejaz, Khaleeq Anwar, Muhammad Ashraf, Chae Woong Lim

Environmental Toxicology and Pharmacology > 2009 > 28 > 1 > 42-51

Angiogenesis, the formation of new blood vessels, is vital for embryonic development and disruption of this process can be a powerful mechanism of abortion. Over the last few decades there has been increasing global concern regarding the public health impact attributed to environmental smoke pollution. However, no study has yet examined the relation between exhaust from 2-stroke auto-rickshaws and...

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INFONA - science communication portal

Search results for: Chae Woong LIM

Experimental infection of dogs with severe fever with thrombocytopenia syndrome virus: Pathogenicity and potential for intraspecies transmission

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced lipotoxicity and steatohepatitis in vitro

Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model

Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice

Developmental competence and cryotolerance of caprine parthenogenetic embryos cultured in chemically defined media

Experimental infection of cows with newly isolated Akabane virus strain (AKAV-7) causing encephalomyelitis

Nasal immunization with M cell-targeting ligand-conjugated ApxIIA toxin fragment induces protective immunity against Actinobacillus pleuropneumoniae infection in a murine model

Depletion of Foxp3+ Regulatory T Cells Promotes Profibrogenic Milieu of Cholestasis-Induced Liver Injury

Toll‐like receptor 7‐mediated type I interferon signaling prevents cholestasis‐ and hepatotoxin‐induced liver fibrosis

Effects of glass bead size, vortexing speed and duration on Eimeria acervulina oocyst excystation

Detrimental effects of cement mortar and fly ash mortar on asthma progression

Differential immune modulation by deoxynivalenol (vomitoxin) in mice

Immune modulatory effects of the foodborne contaminant citrinin in mice

3,3′-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice

Vascular and Morphogenetic Abnormalities Associated with Exposure of Cigarette Smoke Condensate during Chicken and Murine Embryogenesis

Pollution dilemma in Asian population: CNG and wound healing

Detrimental effects of cigarette smoke constituents on physiological development of extraocular and intraocular structures

Total Particulate Matter and Wound Healing: An in vivo Study with Histological Insights

Anti-angiogenic activities associated with exposure of environmental smoke solutions from 2-stroke auto-rickshaw

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