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Local topical analgesia changes basal skin perfusion and its regulation. In particular, the response induced by local heating, which in nontreated skin comprises a rapidly increased perfusion followed by a normalization within 30 s, is altered to a delayed and persistent perfusion increase. The response dependency to the analgesia cream application time, that is, the intradermal penetration of the...
The single-fiber laser Doppler flowmetry (SF-LDF) technique has been used to study perfusion within tissues. The insertion of the SF-LDF probe into human skin locally alters microcirculation for more than 70 min after positioning. In this study the SF-LDF and a newly developed laser Doppler imager (LDI) were used to describe the spatial distribution, the intensity, and the temporal course of the trauma...
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