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Background & Aims: The mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK) pathway plays an important role in the regulation of cell growth and differentiation. Constitutively active components of the MEK signaling cascade can induce oncogenic transformation in many cell systems. Downstream MEK signaling also plays an important role in the regulation of...
Cyclooxygenase-derived prostaglandin E 2 (PGE 2 ) is the predominant prostanoid found in most colorectal cancers (CRC) and is known to promote colon carcinoma growth and invasion. However, the key downstream signaling pathways necessary for PGE 2 -induced intestinal carcinogenesis are unclear. Here we report that PGE 2 indirectly transactivates PPARδ through PI3K/Akt...
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