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AbstractThe effects of the muscarinic antagonists, scopolamine HBr and MeBr, a cholinesterase inhibitor, E2020, and K+ channel blockers, 4-aminopyridine (4-AP) and apamin, on the performance of rats in a delayed matching to position (DMTP) task were examined. The percentage of correct choices (choice accuracy), number of trials completed and intertrial intervals were measured. Discriminability and...
The autoradiographic [ 14 C]2-deoxyglucose procedure was used to map function-related alterations in local cerebral glucose use following acute administration of the α 2 -adrenoceptor antagonist, idazoxan (0.3-3 mg kg -1 s.c.). The most prominent feature of the results obtained was the significant reduction in glucose use in certain locus coeruleus projection areas...
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