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Agents which inhibit complement activation protect against myocardial reperfusion injury and may be beneficial in xenotransplantation, but it is not known whether complement activation is deleterious following lung preservation and transplantation in an isograft model. Lungs harvested from Lewis rats subjected to 4 C 6 hour preservation in Euro-Collins solution followed by transplantation into...
In an attempt to synthesize stereochemically pure new A, C, D-ring analogs of the natural product complement inhibitor K-76, compounds (20-24) were prepared and the representative one (23) was evaluated for its ability to inhibit complement-mediated erythrocyte lysis in both the classical and alternative pathways. Compounds synthesized as part of this study suggest that the terpenoid diol component...
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