Search results for: Takeharu Nakamata

Items from 1 to 7 out of 7 results

article

The effect of walking speed on gait kinematics and kinetics after endoprosthetic knee replacement following bone tumor resection

Yusuke Okita, Noriatsu Tatematsu, Koutatsu Nagai, Tomitaka Nakayama, more

Gait & Posture > 2014 > 40 > 4 > 622-627

Gait function is one of the most important components of functional outcome evaluation in patients with a tumor around the knee. In addition to walking at a preferred speed, the patients might be sometimes required to walk fast in daily life (e.g., schooling and working) because the major types of bone tumors often occur in adolescence and young adults. Therefore, recovering the ability to walk fast...

article

Perforation of enteric duplication during chemotherapy for osteosarcoma

Tatsuya Morishima, Itaru Kato, Katsutsugu Umeda, Hidefumi Hiramatsu, more

Pediatrics International > 56 > 2 > 279 - 282

A 9‐year‐old boy undergoing chemotherapy for conventional osteosarcoma complained of severe abdominal pain associated with rebound tenderness and muscular defense. Abdominal computed tomography indicated intraperitoneal free air. On surgical investigation, a diverticulum‐like lesion, perforated at the base, was found on the sidewall of the ileum. The anatomic location of the lesion was indicative...

article

Compensation by nonoperated joints in the lower limbs during walking after endoprosthetic knee replacement following bone tumor resection

Yusuke Okita, Noriatsu Tatematsu, Koutatsu Nagai, Tomitaka Nakayama, more

Clinical Biomechanics > 2013 > 28 > 8 > 898-903

Endoprosthetic knee replacement is often used to preserve joint function in patients with bone tumors of the distal femur or proximal tibia. Recently, because of improved oncologic outcome, surgeons are focusing more on the functional outcome of patients with musculoskeletal tumors. We hypothesized that patients who have undergone endoprosthetic knee replacement are forced to compensate for deficiency...

article

Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas

Tomoki Aoyama, Satoshi Nagayama, Takeshi Okamoto, Taisuke Hosaka, more

Cancer Letters > 2002 > 186 > 1 > 49-57

Mice lacking nuclear factor of activated T cell 1 (NFAT1) showed an abnormal proliferation of chondrocytes in articular cartilage and formed an extraosseous cartilaginous mass resembling a neoplastic lesion, suggesting that the NFAT1 gene is a tumor suppressor gene in cartilaginous neoplasms. Here we performed mutation analyses of the NFAT1 gene in human cartilaginous tumors including 30 chondrosarcomas...

article

Morphological and biological heterogeneity of three tumorigenic cell lines derived from a single p53-/- osteoblast-like cell line, MMC2

Hiroshi Murakami, Tomitaka Nakayama, Koichi Nishijo, Taisuke Hosaka, more

Cancer Letters > 2002 > 182 > 2 > 203-211

Osteosarcoma is a malignant tumor with heterogeneous features both in histological and biological aspects. We have established three tumorigenic cell lines, MMOS1, MMOS2, and MMOS3, from three independent tumors that developed in nude mice after the inoculation of MMC2, an osteoblast-like cell line derived from p53-/- mice. Expression patterns of the osteoblast-related genes showed a marked difference...

article

A Novel Type of EWS-CHOP Fusion Gene in Two Cases of Myxoid Liposarcoma

Taisuke Hosaka, Yasuaki Nakashima, Katsuyuki Kusuzaki, Hiroaki Murata, more

The Journal of Molecular Diagnostics > 2002 > 4 > 3 > 164-171

Fusion genes consisting of TLS/FUS and CHOP or EWS and CHOP are characteristic markers for myxoid/round cell liposarcomas (MLS/RCLS). Several different structures of the fusion genes were reported in the case of the TLS/FUS-CHOP form, whereas only one type of structure has so far been found for the EWS-CHOP form, which consisted of exons 1 to 7 of the EWS and exons 2 to 4 of the CHOP gene. Here we...

article

Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells

Takeshi Okamoto, Tomoki Aoyama, Tomitaka Nakayama, Takeharu Nakamata, more

Biochemical and Biophysical Research Communications > 2002 > 295 > 2 > 354-361

Mesenchymal stem cells (MSCs) are bone marrow stroma-derived cells, which can differentiate into several types of mesenchymal tissues. Although regarded as tissue-specific stem cells, human MSCs (hMSCs) have a low proliferative ability with a finite life span, which is a hurdle to further analysis of their biology. Here we attempted to establish immortalized hMSCs by retrovirus-mediated gene transfer...

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Search results for: Takeharu Nakamata

The effect of walking speed on gait kinematics and kinetics after endoprosthetic knee replacement following bone tumor resection

Perforation of enteric duplication during chemotherapy for osteosarcoma

Compensation by nonoperated joints in the lower limbs during walking after endoprosthetic knee replacement following bone tumor resection

Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas

Morphological and biological heterogeneity of three tumorigenic cell lines derived from a single p53-/- osteoblast-like cell line, MMC2

A Novel Type of EWS-CHOP Fusion Gene in Two Cases of Myxoid Liposarcoma

Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells

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