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The genetic diversity of the major histocompatibility complex (MHC) class I molecules of pigs has not been well characterized. Therefore, the influence of MHC genetic diversity on the immune‐related traits of pigs, including disease resistance and other MHC‐dependent traits, is not well understood. Here, we attempted to develop an efficient method for systemic analysis of the polymorphisms in the...
The RV144 HIV vaccine trial in Thailand elicited antibody responses to the envelope of HIV‐1, which correlated significantly with the risk of HIV‐1 acquisition. Human leukocyte antigen (HLA) class II molecules are essential in antigen presentation to CD4 T cells for activation of B cells to produce antibodies. We genotyped the classical HLA‐DRB1, DQB1, and DPB1 genes in 450 individuals from the placebo...
Inflammatory demyelinating disease (IDD), which includes multiple sclerosis (MS) and neuromyelitis optica (NMO), affects the central nervous system. Chemokine ligand 2 (CCL2/MCP‐1) is considered an important contributor to the development or progression of IDD. However, genetic association studies of Asian populations are lacking. In this study, we investigated a possible association between CCL2...
This study investigated whether killer‐cell immunoglobulin‐like receptor (KIR) genes and human leukocyte antigen (HLA)‐C alleles, receptors and ligands of natural killer cells are associated with the development of human papillomavirus (HPV)‐related cervical disease in Korean women. Blood samples from 132 women with HPV‐related cervical disease and 159 women without HPV infection were collected for...
We previously reported the development of genomic‐DNA‐based high‐resolution genotyping methods for SLA‐DQB1 and DRB1. Here, we report the successful typing of SLA‐DQA using similar methodological principles. We designed a method for comprehensive genotyping of SLA‐DQA using intronic sequence information of SLA‐DQA exon 2 that we had obtained from 12 animals with different SLA‐DQB1 genotypes. We expanded...
In an attempt to enable comprehensive high‐resolution genotyping of the swine leukocyte antigen (SLA) gene, we performed a systemic analysis of nucleotide polymorphisms at introns 1 and 2 and exon 2 from diverse alleles of SLA‐DRB1 and DRB1 pseudogenes. We amplified and cloned 16 partial sequences of SLA‐DRB1 and DRB2 introns 1 and 2 from different alleles, and analyzed them together with sequences...
To enable the efficient analysis of a highly polymorphic swine major histocompatibility complex (MHC) class II gene, swine leukocyte antigen (SLA)‐DQB1, we developed a simple and comprehensive high‐resolution genotyping protocol. To obtain sufficient sequence information to design a set of common genotyping primers for SLA‐DQB1, we cloned SLA‐DQB1 introns 1 and 2 from 11 alleles with official four‐digit...
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