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Recent findings of extensive alternative splicing events occurring in eukaryotic organisms have provided a possible explanation for the puzzling discrepancy between the number of genes and high genome complexity. Most alternative splicing events in eukaryotic genomes are detected using sequence fragments produced by high throughput genomic technologies, such as expressed sequence tags (EST) sequencing...
In the present work we report the generation of a new line of α-synuclein (α-SYN) transgenic mice in which the human wild-type α-SYN cDNA is expressed under the control of a tyrosine hydroxylase (TH) promoter. We provide evidence that the ectopic protein is found in TH expressing neurons of both central and peripheral nervous systems. The transgene is expressed very early in development coinciding...
RNA viruses like HIV and HCV have an extraordinary evolutionary potential to escape from both immune pressures and targeted drug therapies. In HIV infections, the emergence of drug resistant strains is of particular interest, as it complicates the choice of an optimal follow-up regimen. A series of bioinformatics tools for predicting drug resistance were previously developed to support physicians...
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