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SummaryBackground Clinical trials suggest an increased frequency of restenosis after coronary intervention in left anterior descending (LAD) compared to the left circumflex or right coronary arteries. Experimental studies correlate stent-induced arterial injury and the extent of neointima formation. This study investigates whether the coronary artery affects the relationship between arterial injury...
Summary Background Clinical trials suggest an increased frequency of restenosis after coronary intervention in left anterior descending (LAD) compared to the left circumflex or right coronary arteries. Experimental studies correlate stent-induced arterial injury and the extent of neointima formation. This study investigates whether the coronary artery affects the relationship between arterial injury...
We designed chimeric DNA-RNA hammerhead ribozymes (RZ) to conserved mRNA for porcine and human PCNA. In vitro studies included RZ cleavage and serum stability. In vivo we assessed RZ effect on DNA synthesis and proliferation of cultured porcine and human vascular SM cells. We then studied, in a stent model, 18 non lipemic, adult pigs (26 coronaries) treated by local infusion of 180 μgm at the angioplasty...
ReoMI (ReoPro in MI) is a multicenter pilot study to assess the efficacy of ReoPro in attaining primary reperfusion in acute myocardial infarction. Patients with acute Q-wave MI, presenting within 6 hours of chest pain are treated with aspirin (325 mg po), heparin (70 u/kg iv) and ReoPro bolus (0.25 mg/kg iv) followed by continuous infusion (0.10 mg/kg) in the emergency room. All patients undergo...
Background: We hypothesized that a balloon based liquid β-emitting brachytherapy would result in homogeneous dose distribution and more effectively inhibit stent restenosis.Methods and Results: Efficacy of Re 188 (β - ; t 12 = 17 hours) filled balloon catheter was tested in a 30 day porcine coronary model of in-stent restenosis in a randomized operator blinded...
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