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BACKGROUNDThe P‐Capt prion reduction filter (MacoPharma) removes prion infectivity in model systems. This independent evaluation assesses prion removal from endogenously infected animal blood, using CE‐marked P‐Capt filters, and replicates the proposed use of the filter within the UK Blood Services.
STUDY DESIGN AND METHODSTwo units of blood, generated from 263K scrapie–infected hamsters, were processed...
Infection with the bacterium Clostridium difficile causes symptoms ranging from mild to severe diarrhoea with life-threatening complications and remains a significant burden to healthcare systems throughout the developed world. Two potent cytotoxins, TcdA and TcdB are the prime mediators of the syndrome and rapid neutralisation of these would afford significant benefits in disease management. In the...
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