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Development of effective drug regimens for AIDS can be aided by knowledge of the resistance patterns evoked by the agents. Recently foscamet(PFA)-resistant strains of HIV have been identified that exhibit increased susceptibility to AZT. Conversely, AZT resistance mutations can reverse PFA resistance. HIV strains that are coresistant to PFA and AZT have not yet been identified by in vitro selection...
During our efforts to discover safe and effective anti-HBV and anti-HIV nucleosides, a number of enantiomerically pure dioxolane nucleosides were synthesized. From these studies, several promising dioxolane nucleosides had dual activity, including DXG, DAPD, ADP, and ACPD. In vitro and in vivo pharmacokinetic studies demonstrated that DAPD, ADP and ACPD served as prodrugs of DXG in rhesus monkeys...
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