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A series of 3‐nitrochromenes were designed and synthesized. These compounds showed good inhibitory activity against thioredoxin reductase (TrxR) and the proliferation of A549 cancer cells. The structure–activity relationship analysis indicates that the 3‐nitrochromene scaffold is the crucial pharmacophore for achieving good inhibitory activity. The bromo‐substitutions at the 6‐ and 8‐position of 3‐nitrochromene...
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