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The study was performed to describe the time course of serum cardiac troponin T (cTnT) elevations for the early detection of anthracycline cardiotoxicity. cTnT was analyzed serially in 78 patients with hematological malignancies receiving 142 treatment cycles including various anthracyclines. cTnT positivity was defined as an increase in cTnT 0.03ng/ml and was observed in 12 patients (15%) during...
Introduction: Proteinase 3 (Pr3) is the major antigen for autoantibodies against cytoplasmatic components of neutrophils (c-ANCA) in Wegener's Granulomatosis (WG). It has been suggested that c-ANCA recognize different, conformational epitopes and that changes in epitopespecificity of ANCA are related to disease activity.Materials and Methods: Using PCR with tailored EcoRI restriction sites and coding...
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