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The reasons for the uneven worldwide distribution of Type 1 diabetes mellitus have yet to be fully explained. Epidemiological studies have shown a higher prevalence of Type 1 diabetes in northern Europe, particularly in Scandinavian countries, and Sardinia. Recent animal research has uncovered the importance of the generation of elevated levels of glucose, glycerol and other sugar derivatives as a...
S100 protein is a 20 kDa calcium-binding protein that accumulates during CNS maturation in mammals. The human gene coding for the β subunit of S100 protein (S100β) is located on chromosome 21, in a subtelomeric position in 21q22.3. In order to investigate the effect of trisomy 21 on S100β gene expression, we performed Southern, Northern and Western blot analysis on DNA, RNA and protein, respectively,...
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