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2.4 Conclusions These studies demonstrate that noninvasive molecular imaging of protein-protein interactions may enable investigators to determine how intrinsic binding specificities of proteins are regulated in a wide variety of normal and pathophysiologic conditions. These tools provide a platform for detection of regulated and small molecule-induced protein-protein interactions in intact cells...
Current methodologies for quantifying radiolabeled nucleoside monophosphates and nucleoside analogues result in high retention of unphosphorylated guanosine nucleosides in the case of lanthanum chloride precipitation or inconsistent retention of nucleotides in the case of DEAE cellulose filter papers. This study describes an innovative method for quantifying thymidine kinase (TK) activity that is...
Background: Multidrug resistance (MDR) mediated by expression of MDR1 P-glycoprotein (Pgp) represents one of the best characterized barriers to chemotherapy in cancer patients. Positron emission tomography (PET) agents for analysis of Pgp-mediated drug transport activity in vivo would enable noninvasive assessment of chemotherapeutic regimens and MDR gene therapy.Results: Candidate Schiff-base phenolic...
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