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Trophoblast cell lines are important research tools used as a surrogate for primary trophoblast cells in the study of placental function. Because the cellular origins of transformed trophoblasts are likely to be diverse, it would be of value to understand the unique and shared phenotypes of the cells on a global scale. We have compared two widely used cell lines, BeWo and JEG3, by microarray analysis...
Within the placenta, nitric oxide (NO) and prostaglandins (e.g. PGI 2 , PGE 2 ) are responsible for maintaining normal vasodilatation and mediate their activities through the classical second messengers cGMP and cAMP respectively. Oxidative damage from oxygen free radicals within the placenta have also been implicated in the pathophysiology of preeclampsia and may stimulate the NO/cGMP...
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