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This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this...
An amino acid derivative with a highly fluorescent probe sensitive to the environment was prepared and the conditions for its optimal use in solid-phase peptide synthesis are described.
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