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Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently as a decade ago. In 2005,...
Flywheel energy storage technology has been successfully commercialized for applications requiring high power, high cycle-life, and short storage intervals. High idling losses have prevented the use of flywheel technology in applications that require longer storage intervals, such as grid-based, load-following energy storage. This paper proposes the use of an outer-rotor ac homopolar motor to significantly...
In 1990, Kansas's Mental Health Reform legislation began transferring fiscal support for the delivery of mental health services away from state institutions and into the local community, culminating in the closure of one state hospital facility in 1997. Kansas jails were studied to determine the resulting impact of that hospital closure on the State's jail systems, including whether an increase in...
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