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Antibody drug conjugates (ADC), in which small molecule cytotoxic agents are non-specifically linked to antibodies, can enable targeted delivery of chemotherapeutics to tumor cells. ADCs are often produced and administered as a mixture of conjugated antibodies with different drug to antibody ratios (DAR) resulting in complex and heterogeneous disposition kinetics. We developed a mechanism-based platform...
Immunogenicity (the development of an adaptive immune response reactive with a therapeutic) is a well-described but unwanted facet of biotherapeutic development. There are commonly applied procedures for immunogenicity risk assessment, testing strategies, and bioanalysis. With some modifications, these can be applied to new biotherapeutic modalities. For novel therapies such as antibody-drug conjugates...
Carrasco, M., M. Del Rio, A. Hernanz and M. De La Fuente. Inhibition of human neutrophil functions by sulfated and nonsulfated cholecystokinin octapeptides. Peptides 18(3) 415–422, 1997.—The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10−14 to 10−6M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and...
The effect in vitro of gastrin-17 and gastrin-34 was studied at concentrations from 10 -12 to 10 -6 M on several functions of resting peritoneal macrophages from BALB/c mice: adherence to substrate, mobility (spontaneous and directed by chemical gradient or chemotaxis), and ingestion of inert particles (latex beads) or cells (Candida albicans). Both gastrins, at concentrations...
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