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Ca 2+ signaling plays a central role in activity-dependent regulation of dendritic arborization, but key molecular mechanisms downstream of calcium elevation remain poorly understood. Here we show that the C-terminal region of the Ca 2+ /calmodulin-dependent protein kinase CLICK-III (CL3)/CaMKIγ, a membrane-anchored CaMK, was uniquely modified by two sequential lipidification steps:...
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