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Superoxide anions (O •−2 ) induce oxidative stress and reduce endothelial NO availability by peroxynitrite formation. In human endothelial cells gp91 phox was identified as the limiting subunit of the forming NAD(P)H oxidase. Because endothelin-1 (ET-1) is considered as a pro-atherosclerotic stimulus, we analyzed the effect of ET-1 on gp91 phox expression and O •−...