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Transdermal drug delivery across the highly lipophilic uppermost layer of the skin, the stratum corneum, is highly challenging. Importantly, permeation of hydrophilic small or high molecular weight and charged compounds into the systemic circulation is limited. To successfully deliver hydrophilic drugs, and macromolecular agents of interest, including peptides, DNA and small interfering RNA, many...
Punctal plugs (PPs) are miniature medical implants that were initially developed for the treatment of dry eyes. Since their introduction in 1975, many PPs made from different materials and designs have been developed. PPs, albeit generally successful, suffer from drawbacks such as epiphora and suppurative canaliculitis. To overcome these issues intelligent designs of PPs were proposed (e.g. SmartPLUG™...
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