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This study tests the hypothesis that hyperinsulinemic (HI) obese subjects respond differently from normoinsulinemics (NI) to changes in composition of hypoenergetic diets. Twenty-seven obese male subjects, 13 HI and 14 NI, were fed for 4 weeks either a high protein (HP) or a high carbohydrate (HC) hypoenergetic diet providing 80% of their resting energy expenditure (REE). On the HP diet weight loss...