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We investigated the effects of marimastat, an inhibitor of TNF-α converting enzyme and matrix metalloproteinases, and anti-TNF-α antibodies on a murine model for sepsis, and on arthritis in human TNF-α transgenic mice. Marimastat (25-200mg/kg) inhibited lipopolysaccharide (LPS)-induced soluble TNF-α production in mice in a dose-dependent manner. At an oral dose of 200mg/kg, marimastat almost completely...
We investigated the role of leukotriene B 4 (LTB 4 ) in murine arthritis models using a leukotriene A 4 (LTA 4 ) hydrolase inhibitor, SA6541. SA6541 inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo. SA6541 also inhibited LTA 4 -induced hyperproliferation of synovial stromal...
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