Search results for: Timothy Madden

Items from 1 to 20 out of 27 results

article

A phase 1/2a safety, pharmacokinetics, and efficacy study of the novel nucleoside analog FF‐10502‐01 for the treatment of advanced solid tumors

Filip Janku, Milind M. Javle, Shiraj Sen, Shubham Pant, more

Cancer > 129 > 10 > 1537 - 1546

Background The nucleoside FF‐10502‐01, structurally similar to but with different biologic effects than gemcitabine, shows promising activity both alone and combined with cisplatin in preclinical gemcitabine‐resistant tumor models. We conducted an open‐label, single‐arm, 3 + 3 first‐in‐human trial to explore the safety, tolerability, and antitumor activity of FF‐10502‐01 in patients with solid tumors...

article

Enterprise strategy concept, measurement, and validation: Integrating stakeholder engagement into the firm's strategic architecture

Veselina Vracheva, William Q. Judge, Timothy Madden

European Management Journal > 2016 > 34 > 4 > 374-385

A firm's enterprise strategy is its overarching strategic orientation, addressing questions regarding its general purpose and the specific nature of its relationships with stakeholders along two dimensions: (a) scope, which represents the range of stakeholders the organization attempts to serve, and (b) type, which represents the general motivation behind stakeholder initiatives. The corporate social...

chapter

Dose Individualization for High-dose anti-cancer Chemotherapy

Gary L. Rosner, Peter Müller, Feng Tang, Timothy Madden, more

The International Series in Engineering and Computer Science > Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3 > Pharmacotherapy > 239-253

Summary We described the use of Bayesian decision theory in the design of a dose-individualization study. The particular application was treatment of leukemia with high-dose chemotherapy and stem-qell transplantation. Data were assumed already available from earlier phase II studies in which patients received a fixed high dose of chemotherapy. In one of the earlier studies, patients received a low,...

chapter

Dose Individualization for High-dose anti-cancer Chemotherapy

Gary L. Rosner, Peter Müller, Feng Tang, Timothy Madden, more

The International Series in Engineering and Computer Science > Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3 > Pharmacotherapy > 239-253

article

Optimization of Thermal Kinetic Inductance Detectors for X-ray Spectroscopy

Thomas W. Cecil, Lisa Gades, Timothy Madden, Daikang Yan, more

IEEE Transactions on Applied Superconductivity > 2015 > 25 > 3-1 > 1 - 5

Thermal kinetic inductance detectors (TKIDs) are promising new detectors for use in X-ray spectroscopy because of the relative ease with which they can be fabricated into large arrays. While initial results have hinted at their resolution capability, the ultimate resolution achievable with these detectors has not been described. Using a bolometer matrix formalism, we examine the parameter space of...

chapter

Real-time MPI-based software for processing of XPCS data

Timothy Madden, Sufeng Niu, Suresh Narayanan, Alec Sandy, more

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) > 1 - 5

2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

We describe a software library, called MPIFCCD, based on the Message Passing Interface (MPI) for real-time parallel computing on data continuously streamed from the Frame Store Fast Charge-Coupled Device (FSFCCD) Detector located at the Advanced Photon Source (APS) at Argonne National Laboratory. The FSFCCD is used to collect data for X-ray Photon Correlation Spectroscopy (XPCS) experiments at Sector...

article

A Biodistribution and Toxicity Study of Cobalt Dichloride-N-Acetyl Cysteine in an Implantable MRI Marker for Prostate Cancer Treatment

Steven J. Frank, Mary J. Johansen, Karen S. Martirosyan, Mihai Gagea, more

International Journal of Radiation Oncology, Biology, Physics > 2013 > 85 > 4 > 1024-1030

C4, a cobalt dichloride-N-acetyl cysteine complex, is being developed as a positive-signal magnetic resonance imaging (MRI) marker to localize implanted radioactive seeds in prostate brachytherapy. We evaluated the toxicity and biodistribution of C4 in rats with the goal of simulating the systemic effects of potential leakage from C4 MRI markers within the prostate.9-μL doses (equivalent to leakage...

article

d-Glucose and d-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated d-glucose, d-mannose, and 2-deoxy-d-glucose

Izabela Fokt, Stanislaw Skora, Charles Conrad, Timothy Madden, more

Carbohydrate Research > 2013 > 368 > Complete > 111-119

Altered carbohydrate metabolism in cancer cells was first noted by Otto Warburg more than 80years ago. Upregulation of genes controlling the glycolytic pathway under normoxia, known as the Warburg effect, clearly differentiates malignant from non-malignant cells. The resurgence of interest in cancer metabolism aims at a better understanding of the metabolic differences between malignant and non-malignant...

article

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway

Ke Sai, Shuzhen Wang, Veerakumar Balasubramaniyan, Charles Conrad, more

Journal of Neuro-Oncology > 2012 > 107 > 3 > 487-501

Glioma stem-like cells (GSCs) may be the initiating cells in glioblastoma (GBM) and contribute to the resistance of these tumors to conventional therapies. Development of novel chemotherapeutic agents and treatment approaches against GBM, especially those specifically targeting GSCs are thus necessary. In the present study, we found that a novel Janus kinase 2/Signal Transducer and Activator of Transcription...

article

Clofarabine ± Fludarabine with Once Daily i.v. Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and MDS

Borje S. Andersson, Benigno C. Valdez, Marcos de Lima, Xuemei Wang, more

Biology of Blood and Marrow Transplantation > 2011 > 17 > 6 > 893-900

Although a combination of i.v. busulfan (Bu) and fludarabine (Flu) is a safe, reduced-toxicity conditioning program for acute myelogenous leukemia/myelodysplastic syndromes (AML/MDS), recurrent leukemia posttransplantation remains a problem. To enhance the conditioning regimen’s antileukemic effect, we decided to supplant Flu with clofarabine (Clo), and assayed the interactions of these nucleoside...

article

Intravenous Busulfan Plus Melphalan Is a Highly Effective, Well-Tolerated Preparative Regimen for Autologous Stem Cell Transplantation in Patients with Advanced Lymphoid Malignancies

Partow Kebriaei, Timothy Madden, Reza Kazerooni, Xuemei Wang, more

Biology of Blood and Marrow Transplantation > 2011 > 17 > 3 > 412-420

We investigated the administration of intravenous (i.v.) busulfan (Bu) combined with melphalan (Mel) in patients with advanced lymphoid malignancies undergoing autologous stem cell transplantation. Bu 130 mg/m ² was infused daily for 4 days, either as a fixed dose per body surface area (BSA), or to target an average daily area under the curve of 5000 μmol-min, determined by a test dose of...

article

d-Glucose- and d-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-d-glucoses and -d-mannoses

Izabela Fokt, Slawomir Szymanski, Stanislaw Skora, Marcin Cybulski, more

Carbohydrate Research > 2009 > 344 > 12 > 1464-1473

Modified d-glucose and d-mannose analogs are potentially clinically useful metabolic inhibitors. Biological evaluation of 2-deoxy-2-halo analogs has been impaired by limited availability and lack of efficient methods for their preparation. We have developed practical synthetic approaches to 2-deoxy-2-fluoro-, 2-chloro-2-deoxy-, 2-bromo-2-deoxy-, and 2-deoxy-2-iodo derivatives of d-glucose and d-mannose...

article

Pharmacokinetics of Once-Daily IV Busulfan as Part of Pretransplantation Preparative Regimens: A Comparison with an Every 6-Hour Dosing Schedule

Timothy Madden, Marcos de Lima, Neil Thapar, John Nguyen, more

Biology of Blood and Marrow Transplantation > 2007 > 13 > 1 > 56-64

In pretransplantation therapy busulfan is typically given every 6 hours. We infused busulfan once daily at 130 mg/m ² for 4 days, performing pharmacokinetic analyses on plasma concentration-time data (n = 60 patients) on days 1, 3, and/or 4. Mean (percent coefficient of variation) maximum concentration, volume of distribution, half-life, and clearance were 3.6 μg/mL (13.8%), 22.6 L/m ²...

article

Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids

Peiying Yang, Diana Chan, Edward Felix, Timothy Madden, more

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) > 2006 > 75 > 6 > 385-395

Cyclooxygenase and lipoxygenase arachidonate products, including prostaglandins (PGs), leukotrienes (LTs), and hydroxyeicosatetraenoic acids (HETEs), are known to modulate inflammation within tissues and can serve as important etiologic factors in carcinogenesis. Eicosanoid content in tissues is typically determined either as a single molecular species through antibody-based assays or by high-performance...

article

Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation

Hai Tran, Demetrios Petropoulos, Laura Worth, Craig A. Mullen, more

Biology of Blood and Marrow Transplantation > 2004 > 10 > 11 > 805-812

We investigated the pharmacokinetics (PK) of a recently approved intravenous busulfan (IVBU) formulation as a part of the preparative regimen in 20 children with advanced hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation. Seventeen patients received a thiotepa, IVBU, and cyclophosphamide-based regimen, and 3 patients received an IVBU and cyclophosphamide-based...

article

Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors

Hai T. Tran, George R. Blumenschein, Charles Lu, Christina A. Meyers, more

Cancer Chemotherapy and Pharmacology > 2004 > 54 > 4 > 308-314

Purpose. Preclinical studies have demonstrated a synergistic effect with the angiogenesis inhibitor TNP-470 and several cytotoxic agents. A recent clinical trial with the combination of paclitaxel and TNP-470 has shown promising effects. The present study was designed to determine the toxicity and pharmacokinetics of carboplatin in combination with TNP-470 in comparison with the doublet regimen of...

article

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

Henry Q. Xiong, Roy Herbst, Silvana C. Faria, Catherine Scholz, more

Investigational New Drugs > 2004 > 22 > 4 > 459-466

Purpose. To evaluate the biologic effects of SU6668 in patients with solid tumors using comprehensive measures of pharmacokinetics (PK), functional imaging, and tissue correlative studies. Experimental design. Eligible patients with tumors accessible for core needle biopsy were treated with SU6668 at doses of 200 or 400 mg/m²/day. Functional computed tomography (CT) scan and dynamic contrast-enhanced...

article

Final results of a phase I and pharmacokinetic study of -methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors

Mary Johansen, Thomas Zukowski, Paulo M. Hoff, Robert A. Newman, more

Cancer Chemotherapy and Pharmacology > 2004 > 53 > 5 > 370-376

Purpose. To determine the maximum tolerated dose (MTD) of -methylene-10-deazaaminopterin (MDAM), a unique antifolate structurally similar to methotrexate (MTX), in the treatment of patients with solid tumors and to characterize toxicity and pharmacokinetic profiles of MDAM administered intravenously for five consecutive days repeated every 21days. Methods. A group of 18 patients with treatment-refractory...

article

Intravenous busulfan in pretransplant chemotherapy: bioavailability and patient benefit

Borje S. Andersson, Ashwin Kashyap, Daniel Couriel, Timothy Madden, more

Biology of Blood and Marrow Transplantation > 2003 > 9 > 11 > 722-724

article

Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells

Peiying Yang, Edward Felix, Timothy Madden, Susan M. Fischer, more

Analytical Biochemistry > 2002 > 308 > 1 > 168-177

This paper describes a rapid and simple technique for the simultaneous quantitative analysis of PGE ₂ , PGE ₃ , and other closely related prostaglandins from cultured cells using liquid chromatography/electrospray ionization tandem mass spectrometry. This method permits quantification of selected individual prostaglandins derived either from arachidonic acid (AA) or eicosapentaenoic...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Timothy Madden

A phase 1/2a safety, pharmacokinetics, and efficacy study of the novel nucleoside analog FF‐10502‐01 for the treatment of advanced solid tumors

Enterprise strategy concept, measurement, and validation: Integrating stakeholder engagement into the firm's strategic architecture

Dose Individualization for High-dose anti-cancer Chemotherapy

Dose Individualization for High-dose anti-cancer Chemotherapy

Optimization of Thermal Kinetic Inductance Detectors for X-ray Spectroscopy

Real-time MPI-based software for processing of XPCS data

A Biodistribution and Toxicity Study of Cobalt Dichloride-N-Acetyl Cysteine in an Implantable MRI Marker for Prostate Cancer Treatment

d-Glucose and d-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated d-glucose, d-mannose, and 2-deoxy-d-glucose

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway

Clofarabine ± Fludarabine with Once Daily i.v. Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and MDS

Intravenous Busulfan Plus Melphalan Is a Highly Effective, Well-Tolerated Preparative Regimen for Autologous Stem Cell Transplantation in Patients with Advanced Lymphoid Malignancies

d-Glucose- and d-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-d-glucoses and -d-mannoses

Pharmacokinetics of Once-Daily IV Busulfan as Part of Pretransplantation Preparative Regimens: A Comparison with an Every 6-Hour Dosing Schedule

Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids

Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation

Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

Final results of a phase I and pharmacokinetic study of -methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors

Intravenous busulfan in pretransplant chemotherapy: bioavailability and patient benefit

Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells

Filter options

Publication date

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Timothy Madden

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options