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BackgroundMutations of the EVER1 and EVER2 genes cause epidermodysplasia verruciformis (EV), a genodermatosis associated with squamous cell carcinoma (SCC). Recently, it has been found that the rs7208422 (c.917A→T, p.N306l) polymorphism in the EVER2 gene is related to an increased risk of SCC in patients with conditions other than EV. We hypothesized that this polymorphism might be also associated...
Systemic sclerosis (SSc) is characterized by generalized, immunologically induced fibrosis. Major pathogenetic abnormalities in SSc include abnormal activation of T lymphocytes, i.e. increased expression of IL-2 mRNA. Recent studies have shown that prolactin exerts major immunoregulatory effects. Since prolactin and IL-2 share a common signal transducer and activator of transcription (STAT5), we...
Introduction: There is strong evidence that antitumor activity of interleukin-12 (IL-12) in vivo is mediated, in part, through interferon (IFN-γ) produced by IL-12-stimulated NK and T cells. Since IFN-γ and tumor necrosis factor-α (TNF-α) have been reported to synergize in antitumor effects in a number of models, we decided to examine whether the combined treatment with recombinant mouse IL-12 and...
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