Search results for: Shinwu Jeong

Items from 1 to 14 out of 14 results

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Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

M. Elizabeth Fini, Stephen G. Schwartz, Xiaoyi Gao, Shinwu Jeong, more

Progress in Retinal and Eye Research > 2017 > 56 > C > 58-83

Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes; this provides the potential for a highly personalized pharmacological response. Studies attempting to define genetic...

article

Clusterin in the eye: An old dog with new tricks at the ocular surface

M. Elizabeth Fini, Aditi Bauskar, Shinwu Jeong, Mark R. Wilson

Experimental Eye Research > 2016 > 147 > C > 57-71

The multifunctional protein clusterin (CLU) was first described in 1983 as a secreted glycoprotein present in ram rete testis fluid that enhanced aggregation (‘clustering’) of a variety of cells in vitro. It was also independently discovered in a number of other systems. By the early 1990s, CLU was known under many names and its expression had been demonstrated throughout the body, including in the...

article

A cell‐based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair

Gabriel M. Gordon, Adriana J. LaGier, Corinne Ponchel, Aditi Bauskar, more

Wound Repair and Regeneration > 24 > 1 > 89 - 99

The goal of this study was to develop and validate a simple but quantitative cell‐based assay to identify compounds that might be used pharmaceutically to give tissue repair a more regenerative character. The cornea was used as the model, and some specific aspects of repair in this organ were incorporated into assay design. A quantitative cell‐based assay was developed based on transcriptional promoter...

article

Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation

Shinwu Jeong, Dolena R. Ledee, Gabriel M. Gordon, Tatsuo Itakura, more

The American Journal of Pathology > 2012 > 180 > 5 > 2028-2039

Uncontrolled increases of matrix metalloproteinase-9 (MMP-9) activity have been causally linked to epithelial barrier disruption and severe symptoms of inflammatory diseases such as dry eye (DE). The data presented here show that the anti-inflammatory, cytoprotective intracellular and extracellular chaperone protein clusterin (CLU) interacts with MMP-9 both inside and outside epithelial cells. CLU...

article

Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors

Jinho Lee, Kyoung-Hee Kim, Shinwu Jeong

Bioorganic & Medicinal Chemistry Letters > 2011 > 21 > 14 > 4203-4205

A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.

article

JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative

Dong-Myung Kim, Misun Won, Chung-Sook Chung, Semi Kim, more

Apoptosis > 2010 > 15 > 12 > 1540-1548

Diarylsulfonylureas are potent antitumor agents that have been tested in clinical trials. However, detailed mechanisms of their apoptotic activity remain unclear. Here, we report a new diarylsulfonylurea derivative, LB2A, that upregulates RhoB, thereby inducing potent apoptosis in HCT-116 human colon cancer cells independently of p53 status. LB2A decreased procaspase-3, increased phospho-JNK, and...

article

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors

Jinho Lee, Hwangeun Choi, Kyoung-Hee Kim, Shinwu Jeong, more

Bioorganic & Medicinal Chemistry Letters > 2008 > 18 > 7 > 2292-2295

A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ ⁶ -isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.

article

Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island

Joy C. Lin, Shinwu Jeong, Gangning Liang, Daiya Takai, more

Cancer Cell > 2007 > 12 > 5 > 432-444

Epigenetic silencing of tumor suppressor genes is generally thought to involve DNA cytosine methylation, covalent modifications of histones, and chromatin compaction. Here, we show that silencing of the three transcription start sites in the bidirectional MLH1 promoter CpG island in cancer cells involves distinct changes in nucleosomal occupancy. Three nucleosomes, almost completely absent from the...

article

3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

Jinho Lee, Taesik Park, Shinwu Jeong, Kyoung-Hee Kim, more

Bioorganic & Medicinal Chemistry Letters > 2007 > 17 > 5 > 1284-1287

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

article

Lasonolide A: Structural Revision and Total Synthesis

Ho Young Song, Jung Min Joo, Jung Won Kang, Dae-Shik Kim, more

The Journal of Organic Chemistry > 2003 > 68 > 21 > 8080 - 8087

article

Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

Bomsoo Cho, Hansoo Lee, ShinWu Jeong, Yung-Jue Bang, more

Biochemical and Biophysical Research Communications > 2003 > 307 > 1 > 52-63

Previously, we reported the identification and characterization of a novel cancer/testis antigen gene, CAGE ⁴ , that was expressed in various histological types of tumors, but not in normal tissues, with the exception of the testis. To date, molecular mechanisms for the expression of CAGE have never been studied. In our expression analysis, we found that some cancer cell lines did not express...

article

Synthesis of (+)-Lasonolide A: (-)-Lasonolide A is the biologically active enantiomer

Eun Lee, Ho Young Song, Jung Min Joo, Jung Won Kang, more

Bioorganic & Medicinal Chemistry Letters > 2002 > 12 > 24 > 3519-3520

(+)-Lasonolide A was synthesized following the established procedure. (-)-Lasonolide A was found to be the biologically active enantiomer.

article

Identification of signature genes associated with 5-fluorouracil-resistance in human gastric cancer cells

Saeyoung Park, Mina Lee, Hosoon Lee, Hae-Yeong Kim, more

Biotechnology Letters > 2002 > 24 > 20 > 1651-1657

A comparative cDNA microarray analysis was carried out using human gastric cancer cells and their derivative cells made resistant to 5-fluorouracil. Three genes, SRP72, DNA primase, and caspase-6, were identified that were transiently induced by 5-fluorouracil and also overexpressed in 5-fluorouracil-resistant gastric cancer cells.

article

A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)

Hyunil Lee, Jinho Lee, Sangkyun Lee, Youseung Shin, more

Bioorganic & Medicinal Chemistry Letters > 2001 > 11 > 23 > 3069-3072

Design, synthesis and structure-activity relationship of a class of aryl pyrroles as farnesyltransferase inhibitors are described. In vitro and in vivo evaluation of a panel of these inhibitors led to identification of 2 (LB42908) as a highly potent (IC ₅ ₀ =0.9 nM against H-Ras and 2.4 nM against K-Ras) antitumor agent that is currently undergoing preclinical studies.

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Bioorganic & Medicinal Chemistry Letters (5)
Apoptosis (1)
Biochemical and Biophysical Research Communications (1)
Biotechnology Letters (1)
Cancer Cell (1)
Experimental Eye Research (1)
Progress in Retinal and Eye Research (1)
The American Journal of Pathology (1)
The Journal of Organic Chemistry (1)
Wound Repair and Regeneration (1)
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Search results for: Shinwu Jeong

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