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Trypanosoma cruzi CRK3 gene encodes a Cdc2p related protein kinase (CRK). To establish if it has a role in the regulation of the parasite cell cycle we studied CRK3 expression and activity throughout three life cycle stages. CRK3 from epimastigote soluble extracts interacted with p13 suc1 -beads. Endogenous CRK3 phosphorylated histone H1 and this activity was inhibited by specific CDK inhibitors:...