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The B∗73:01 allele has been a subject of interest since the mid-1990’s, when it was recognized as defining its own lineage, separate from all other HLA-B alleles (Parham et al). Recently, B∗73 has been implicated in the evolution of the Denisovans, an archaic human group, despite the fact that it has not yet been found in a Denisovan specimen (Abi-Rached et al). The theory that B∗73 haplotypes were...
Current Hematopoeitic cell transplant (HCT) donor selection strategies do not include matching at the DP locus and this locus is rarely typed for in either the related or the unrelated potential donor setting. Since the advent of the solid phase assays for detection of anti-HLA antibodies, our ability to successfully detect and determine specificity of both Class I and II antibodies has been greatly...